Dr  Gavin  Williams

Gavin undertook his PhD in Alan Berry's laboratory at the University of Leeds, and stayed on to undertake BBSRC-sponsored postdoctoral work with Dr Berry and Professor Nelson.  Gavin used directed evolution to modify the stereochemical course of enzyme-catalysed bond formation for the first time.  In later work, he broadened the substrate specificity of sialic acid aldolase sufficiently for use in parallel synthesis, before creating a pair of stereochemically complementary aldolases.  He left Leeds to undertake  postdoctoral research in Professor Jon Thorson's lab, University of Wisconsin.

Publications with Professor Nelson:

61 Alan  Berry , Lorna  Farnsworth , Adam  Nelson , Gavin  Williams and Thomas  Woodhall , "Creation of a Pair of Stereochemically Complementary Biocatalysts", J. Am. Chem. Soc. 2006, 128, 16238-16247
Keywords: "Stereochemically diverse libraries" "Directed evolution"

51 Alan  Berry , Adam  Nelson , Gavin  Williams and Thomas  Woodhall , "Structure-guided saturation mutagenesis of N-acetylneuraminic acid lyase for the synthesis sialic acid mimetics", Prot. Eng. Des. Sel. 2005, 18, 239-246
Keywords: "Stereochemically diverse libraries" "Directed evolution"

49 Alan  Berry , Adam  Nelson , Gavin  Williams and Thomas  Woodhall , "Creation of an aldolase for the parallel synthesis of sialic acid mimetics", Angew. Chem., Int. Ed. 2005, 44, 2109-2112
Open Access Version
Keywords: "Stereochemically diverse libraries" "Directed evolution"

46 Alan  Berry , Adam  Nelson , Gavin  Williams and Thomas  Woodhall , "Synthesis of screening substrates for the directed evolution of sialic acid aldolase: Towards tailored enzymes for the preparation of influenza A sialidase inhibitor analogues", Org. Biomol. Chem. 2005, 3, 1795-1800
Open Access Version - provided courtesy of the RSC
Keywords: "Stereochemically diverse libraries" "Directed evolution"

43 Alan  Berry , Adam  Nelson and Gavin  Williams , "Directed Evolution of Enzymes for Biocatalysis and the Life Sciences", Cell. Mol. Life Sci. 2004, 61, 3034-3046
Keywords: "Directed evolution"

33 Alan  Berry , Silvie  Domann , Adam  Nelson and Gavin  Williams , "Modifying the stereochemistry of an enzyme-catalysed reaction by directed evolution", Proc. Natl. Acad. Sci. USA 2003, 100, 3143-3148
Keywords: "Directed evolution"

Research areas

Directed evolution