Dr  Stuart  Warriner

s.l.warriner@leeds.ac.uk

0113 343 6437

Stuart Warriner is a member of the School of Chemistry and the Astbury Centre at the University of Leeds.  We collaborate with him on a number of projects, particularly those involving solid-supported organic synthesis.  For more details of his research, see his web site

Publications with Professor Nelson:

129 Katherine  Abrahams, Del  Besra, Mark  Dow , Adam  Nelson , Luis  Vaz and Stuart  Warriner , "Modular Synthesis of Diverse Natural Product-like Macrocycles: Discovery of Hits with Antimycobacterial Activity", Chem. Eur. J. 2017, 23, 7207-7211
Keywords: "Chemical Genetics" "Diversity-oriented synthesis"

120 Alex   Breeze , George   Burslem , Thomas  Edwards , Hannah  Kyle , Adam  Nelson , P  Prabhakaran, Stuart  Warriner and Andrew  Wilson , "Synthesis of highly functionalised oligobenzamide proteomimetic foldamers by late stage introduction of sensitive groups", Org. Biomol. Chem. 2016, 14, 3782-3786
Keywords: "Chemical Genetics"

119 Alex   Breeze , George   Burslem , Thomas  Edwards , Hannah  Kyle , Adam  Nelson , Stuart  Warriner and Andrew  Wilson , "Towards ‘bionic’ proteins: replacement of continuous sequences from HIF-1alpha with proteomimetics to create functional p300 binding HIF-1alpha mimics", Chem. Commun. 2016, 52, 5421-5424
Keywords: "Chemical Genetics"

116 Anthony  Aimon , Mark  Dow , George  Karageorgis , Adam  Nelson and Stuart  Warriner , "Activity-directed Synthesis with Intermolecular Reactions: Development of a Fragment into a Range of Androgen Receptor Agonists", Angew. Chem. Int. Ed. 2015, 54, 13538-13544
Keywords: "Diversity-oriented synthesis"

114 James  Firth , Richard  Foster , Rachel  Guilleux, Tuomo  Kalliokoski, Steve  Marsden , Remy  Morgantin , Adam  Nelson , Stuart  Warriner and Rong  Zhang , "Exploitation of the Ugi-Joullié reaction in the synthesis of libraries of drug-like bicyclic hydantoins", Synthesis 2015, , 2391-2406
Keywords: "Diversity-oriented synthesis"

113 Alex   Breeze , George   Burslem , Thomas  Edwards , Hannah  Kyle , Adam  Nelson , Jonathan  Stott, Darren  Tomlinson , Stuart  Warriner , Kate  Wickson and Andrew  Wilson , "Exploration of the HIF-1alpha/p300 binding interface using peptide and adhiron phage display technologies to locate binding hot-spots for inhibitor development", Mol. Biosys. 2015, 11, 2738-2749
Keywords: "Chemical Genetics"

107 George  Karageorgis , Adam  Nelson and Stuart  Warriner , "Efficient discovery of bioactive scaffolds by activity-directed synthesis", Nature Chem. 2014, 6, 872-876
Keywords: "Diversity-oriented synthesis"

105 Alex   Breeze , George   Burslem , Thomas  Edwards , Hannah  Kyle , Adam  Nelson , Stuart  Warriner and Andrew  Wilson , "Small Molecule Proteomimetic Inhibitors of the HIF-1alpha/p300 Protein-Protein Interaction", ChemBioChem 2014, 14, 1083-1087
Keywords: "Chemical Genetics"

104 George   Burslem , Andrew  Grant , Tom   James , Paul  MacLellan , Adam  Nelson , Iain  Simpson , Sri  Sridharan and Stuart  Warriner , "A modular lead-oriented synthesis of diverse piperazine, 1,4-diazepane and 1,5-diazocane scaffolds", Org. Biomol. Chem. 2014, 12, 2584-2591
Keywords: "Diversity-oriented synthesis"

102 Sandra  Bell, Jackie  Bond, Julie  Higgins, Heather  Martin , Ewan  Morrison, Adam  Nelson , Darren  Tomlinson and Stuart  Warriner , "High-Content, High-Throughput Screening for the Identification of Cytotoxic Compounds Based on Cell Morphology and Cell Proliferation Markers", Plos ONE 2014, 9, e88338
Keywords: "Chemical Genetics"

96 Mark  Dow , Sushil  Maurya , Adam  Nelson and Stuart  Warriner , "Synthesis of skeletally diverse alkaloid-like molecules: exploitation of metathesis substrates assembled from triplets of building blocks", Beil. J. Org. Chem. 2013, 9, 775-785
Keywords: "Diversity-oriented synthesis"

90 Catherine  Joce , Adam  Nelson , Peter  Stockley, Stuart  Warriner and Rebecca  White, "Design, Synthesis and In Vitro Evaluation of Novel Bivalent S-Adenosylmethionine Analogues", Bioorg. Med. Chem. Lett. 2012, 22, 278-284
Keywords: "Chemical Genetics"

77 Chris  Cordier , Jerome  Hayes, Adam  Nelson , Catherine  O'Leary-Steele and Stuart  Warriner , "A fluorous-tagged Safety Catch Linker for Preparing Heterocycles by Ring-Closing Metathesis", Org. Lett. 2009, 11, 915-918
Keywords: "Diversity-oriented synthesis"

76 Steve  Bartlett , Christian  Einzinger , David  Glowacki , Ben  McKeever-Abbas , Sarah  Murrison , Adam  Nelson , James  Titchmarsh and Stuart  Warriner , "Remarkably slow rotation about a single bond between an sp3-hybridised carbon and an aromatic ring without ortho substituents", Chem. Eur. J. 2009, 15, 2185-2189
Keywords: "Diversity-oriented synthesis"

75 Jamie  Caryl , Catherine  Joce , Adam  Nelson , Peter  Stockley and Stuart  Warriner , "Identification of stable S-adenosylmethionine (SAM) analogues derivatised with bioorthogonal tags: Effect of ligands on the affinity of the E. coli methionine repressor, MetJ, for its operator DNA", Org. Biomol. Chem. 2009, 7, 635-638
Keywords: "Chemical Genetics"

74 Chris  Cordier , Stuart  Leach , Daniel  Morton , Adam  Nelson and Stuart  Warriner , "Synthesis of natural product-like molecules with over eighty distinct skeletons", Angew. Chemie. Int. Ed. 2009, 48, 104-109
Keywords: "Chemical Genetics" "Diversity-oriented synthesis"

71 Chris  Cordier , Stuart  Leach , Daniel  Morton , Adam  Nelson , Catherine  O'Leary-Steele , Stuart  Warriner and Thomas  Woodhall , "An efficient method for synthesising unsymmetrical silaketals: substrates for ring-closing, including macrocycle-closing, metathesis", Org. Biomol. Chem. 2008, 6, 1734-1737
Keywords: "Diversity-oriented synthesis"

69 Chris  Cordier , Stuart  Leach , Gordon  McKiernan , Daniel  Morton , Adam  Nelson and Stuart  Warriner , "A fluorous-tagged linker from which small molecules are released by ring-closing metathesis", J. Org. Chem. 2008, 73, 2752-2759
Keywords: "Diversity-oriented synthesis"

52 Steve  Bartlett , Godfrey  Beddard, Richard  Jackson, Veysel  Kayser, Colin  Kilner , Andrew  Leach, Adam  Nelson , Peter  Oledzki, Peter  Parker, Gavin  Reid and Stuart  Warriner , "Comparison of the ATP binding sites of Protein Kinases using conformationally diverse bisindolylmaleimides", J. Am. Chem. Soc. 2005, 127, 11699-11708
Keywords: "Stereochemically diverse libraries" "Chemical Genetics"

31 Steve  Bartlett , Robert  Hodgson , Joanne  Holland , Matthew  Jones , Colin  Kilner , Adam  Nelson and Stuart  Warriner , "Exploiting predisposition in the stereoselective synthesis of mono-, bi- and tetracyclic oxygen heterocycles: Equilibration between, and trapping of, alternative di- and tetraacetals", Org. Biomol. Chem. 2003, 1, 2393-2402
Open Access Version - provided courtesy of the RSC
Keywords: "Stereochemically diverse libraries" "New strategies for asymmetric synthesis"

19 Stuart  Green , Adam  Nelson , Stuart  Warriner and Ben  Whittaker , "Synthesis and investigation of the configurational stability of some dimethylammonium borate salts", J. Chem. Soc., Perkin Trans. 1 2000, , 4403-4408
Open Access Version - provided courtesy of the RSC

Research areas

Chemical Genetics

Diversity-oriented synthesis