Dr  Joanne  Holland

Joanne Holland graduated with a first class MChem from Leeds in 1999, and joined the Nelson group.  Joanne pioneered the desymmetrisation of centrosymmetric molecules as a tactic in natural product synthesis, and prepared a key intermediate in a total synthesis of Hemibrevetoxin B.  Joanne was supported by a University of Leeds Brotherton scholarship and Pfizer Central Research.  After leaving the group, Joanne was a medicinal chemist with Millennium Pharmaceuticals.

Publications with Professor Nelson:

35 Mark  Anstiss , Joanne  Holland , Adam  Nelson and James  Titchmarsh , "Beyond breaking the mirror plane: The desymmetrisation of centrosymmetric molecules as an efficient strategy for asymmetric synthesis", Synlett 2003, , 1213-1220
Keywords: "New strategies for asymmetric synthesis" "Natural product synthesis"

32 Joanne  Holland , Mark  Lewis and Adam  Nelson , "Desymmetrisation of a Centrosymmetric Diepoxide: Efficient Synthesis of a Key Intermediate in a Total Synthesis of Hemibrevetoxin B", J. Org. Chem. 2003, 68, 747-753
Keywords: "New strategies for asymmetric synthesis" "Natural product synthesis"

31 Steve  Bartlett , Robert  Hodgson , Joanne  Holland , Matthew  Jones , Colin  Kilner , Adam  Nelson and Stuart  Warriner , "Exploiting predisposition in the stereoselective synthesis of mono-, bi- and tetracyclic oxygen heterocycles: Equilibration between, and trapping of, alternative di- and tetraacetals", Org. Biomol. Chem. 2003, 1, 2393-2402
Open Access Version - provided courtesy of the RSC
Keywords: "Stereochemically diverse libraries" "New strategies for asymmetric synthesis"

25 Joanne  Holland , Mark  Lewis and Adam  Nelson , "First desymmetrisation of a centrosymmetric molecule in natural product synthesis: Preparation of a key fragment in the synthesis of Hemibrevetoxin B", Angew. Chem., Int. Ed. 2001, 40, 4082-4084
Keywords: "New strategies for asymmetric synthesis" "Natural product synthesis"

Research areas

Natural product synthesis

New strategies for asymmetric synthesis