Dr  Thomas  Woodhall

Tom joined the group in 2001, following graduation from the University of Swansea with a first class MChem degree.  Tom prepared screening substrates for the directed evolution of aldolases with novel, synthetically useful activities.  The variant enzymes were then exploited in the diastereoselective, parallel synthesis of sialic acid mimetics.  Tom stayed on for a short postdoctoral stint in the group before moving to a postdoctoral position at the University of Aachen.  Tom was supported by a special studentship from BBSRC/EPSRC, and was jointly supervised by Alan Berry.  Tom is now a fire and explosives forensic investigator.

Publications with Professor Nelson:

117 Alan  Berry , Adam  Daniels , Tom  Harman , Tomas  Lebl, Keith   Mullholland, Adam  Nelson , Arwen  Pearson, Jennifer  Stockwell , Chi  Trinh , Claire  Windle and Thomas  Woodhall , "Evaluation of fluoropyruvate as nucleophile in reactions catalysed by N-acetyl neuraminic acid lyase variants: scope, limitations and stereoselectivity", Org. Biomol. Chem. 2015, , in press
Keywords: "Directed evolution"

71 Chris  Cordier , Stuart  Leach , Daniel  Morton , Adam  Nelson , Catherine  O'Leary-Steele , Stuart  Warriner and Thomas  Woodhall , "An efficient method for synthesising unsymmetrical silaketals: substrates for ring-closing, including macrocycle-closing, metathesis", Org. Biomol. Chem. 2008, 6, 1734-1737
Keywords: "Diversity-oriented synthesis"

61 Alan  Berry , Lorna  Farnsworth , Adam  Nelson , Gavin  Williams and Thomas  Woodhall , "Creation of a Pair of Stereochemically Complementary Biocatalysts", J. Am. Chem. Soc. 2006, 128, 16238-16247
Keywords: "Stereochemically diverse libraries" "Directed evolution"

54 Simon  Barrett , Steve  Bartlett , Amanda  Bolt , Alan  Ironmonger , Catherine  Joce , Adam  Nelson and Thomas  Woodhall , "Configurational stability of bisindolylmaleimide cyclophanes: From conformers to the first configurationally stable, atropisomeric bisindolylmaleimides", Chem. Eur. J. 2005, 11, 6277-6285
Open Access Version
Keywords: "Stereochemically diverse libraries"

51 Alan  Berry , Adam  Nelson , Gavin  Williams and Thomas  Woodhall , "Structure-guided saturation mutagenesis of N-acetylneuraminic acid lyase for the synthesis sialic acid mimetics", Prot. Eng. Des. Sel. 2005, 18, 239-246
Keywords: "Stereochemically diverse libraries" "Directed evolution"

49 Alan  Berry , Adam  Nelson , Gavin  Williams and Thomas  Woodhall , "Creation of an aldolase for the parallel synthesis of sialic acid mimetics", Angew. Chem., Int. Ed. 2005, 44, 2109-2112
Open Access Version
Keywords: "Stereochemically diverse libraries" "Directed evolution"

46 Alan  Berry , Adam  Nelson , Gavin  Williams and Thomas  Woodhall , "Synthesis of screening substrates for the directed evolution of sialic acid aldolase: Towards tailored enzymes for the preparation of influenza A sialidase inhibitor analogues", Org. Biomol. Chem. 2005, 3, 1795-1800
Open Access Version - provided courtesy of the RSC
Keywords: "Stereochemically diverse libraries" "Directed evolution"

Research areas

Directed evolution

Stereochemically diverse libraries