Dr  Steve  Bartlett

Steve Bartlett graduated with a first class MChem degree from the University of Leeds in 2000; his degree involved a year in industry working in a medicinal chemistry group at Smithkline Beecham.  He remained in Leeds for his PhD, working with Adam Nelson on a novel project ‘Synthesis, Conformational Studies and Biological Activity of Bis(indolyl)maleimide Cyclophanes’.  Steve won the Cohen prize within the School of Chemistry for making the most important contribution in his PhD to knowledge in Chemistry.

Steve then moved to the University of Bath to a post-doctoral position with Dr James Dowden in the Department of Pharmacy and Pharmacology.  He generated and screened libraries of compounds, in forward chemical genetic assays with zebrafish embryos, to identify novel proteins involved in developmental biology.

Steve has since returned to Leeds and is involved in both sides of several exciting interdisciplinary projects.

Publications with Professor Nelson:

76 Steve  Bartlett , Christian  Einzinger , David  Glowacki , Ben  McKeever-Abbas , Sarah  Murrison , Adam  Nelson , James  Titchmarsh and Stuart  Warriner , "Remarkably slow rotation about a single bond between an sp3-hybridised carbon and an aromatic ring without ortho substituents", Chem. Eur. J. 2009, 15, 2185-2189
Keywords: "Diversity-oriented synthesis"

73 Steve  Bartlett , Heather  Bone , Teresa  Damiano , Julie  Letchford , Adam  Nelson , Alexis  Perry and Melanie  Welham, "Involvement of glycogen synthase kinase-3 in regulation of murine embryonic stem cell self-renewal revealed by a series of bisindolylmaleimides", Chem. Biol. 2008, 16, 15-27
Keywords: "Chemical Genetics"

54 Simon  Barrett , Steve  Bartlett , Amanda  Bolt , Alan  Ironmonger , Catherine  Joce , Adam  Nelson and Thomas  Woodhall , "Configurational stability of bisindolylmaleimide cyclophanes: From conformers to the first configurationally stable, atropisomeric bisindolylmaleimides", Chem. Eur. J. 2005, 11, 6277-6285
Open Access Version
Keywords: "Stereochemically diverse libraries"

52 Steve  Bartlett , Godfrey  Beddard, Richard  Jackson, Veysel  Kayser, Colin  Kilner , Andrew  Leach, Adam  Nelson , Peter  Oledzki, Peter  Parker, Gavin  Reid and Stuart  Warriner , "Comparison of the ATP binding sites of Protein Kinases using conformationally diverse bisindolylmaleimides", J. Am. Chem. Soc. 2005, 127, 11699-11708
Keywords: "Stereochemically diverse libraries" "Chemical Genetics"

40 Steve  Bartlett and Adam  Nelson , "Evaluation of alternative approaches for the synthesis of macrocyclic bisindolylmaleimides", Org. Biomol. Chem. 2004, 2, 2874-2883
Open Access Version - provided courtesy of the RSC
Keywords: "Stereochemically diverse libraries"

39 Steve  Bartlett and Adam  Nelson , "Towards configurationally stable bisindolylmaleimide cyclophanes: Potential tools for investigating protein kinase function", Chem. Commun. 2004, , 1112-1113
Open Access Version - provided courtesy of the RSC
Keywords: "Stereochemically diverse libraries" "Chemical Genetics"

31 Steve  Bartlett , Robert  Hodgson , Joanne  Holland , Matthew  Jones , Colin  Kilner , Adam  Nelson and Stuart  Warriner , "Exploiting predisposition in the stereoselective synthesis of mono-, bi- and tetracyclic oxygen heterocycles: Equilibration between, and trapping of, alternative di- and tetraacetals", Org. Biomol. Chem. 2003, 1, 2393-2402
Open Access Version - provided courtesy of the RSC
Keywords: "Stereochemically diverse libraries" "New strategies for asymmetric synthesis"

Research areas

Chemical Genetics