Chris  Cordier

Chris Cordier graduated in 2003 from the University of Leeds with a first class BSc(Hons) degree in Chemistry and Pharmacology, receiving the Elaine Hare Three Year Prize awarded for the best performance of any third year chemist.  During his degree, Chris interned at the Gray Cancer Institute synthesising and evaluated in vitro novel inhibitors of an enzyme which is over-expressed in hypoxic tumours.  Following his degree, Chris carried out a summer studentship under the supervision of Prof. Adam Nelson synthesising a diverse library of aminoglycosides sponsored by GSK.
 
Chris began his Wellcome Trust Prize Ph.D Studentship in 2003 on the Molecular Basis of Biological Mechanisms, run by the Astbury Centre. His foundation year included research projects in Biochemistry (with Prof. M. McPherson), Chemical Biology (with Prof. P. Stockley) and in Chemistry (with Prof. A. Nelson). In his PhD, Chris prepared a diverse library compounds with "privileged" natural product-like motifs.
Chris secured a prestigious Herschel Smith postdoctoral fellowship in organic chemistry, and he works in close association with Professor Ian Paterson FRS at the University of Cambridge.

Publications with Professor Nelson:

77 Chris  Cordier , Jerome  Hayes, Adam  Nelson , Catherine  O'Leary-Steele and Stuart  Warriner , "A fluorous-tagged Safety Catch Linker for Preparing Heterocycles by Ring-Closing Metathesis", Org. Lett. 2009, 11, 915-918
Keywords: "Diversity-oriented synthesis"

74 Chris  Cordier , Stuart  Leach , Daniel  Morton , Adam  Nelson and Stuart  Warriner , "Synthesis of natural product-like molecules with over eighty distinct skeletons", Angew. Chemie. Int. Ed. 2009, 48, 104-109
Keywords: "Chemical Genetics" "Diversity-oriented synthesis"

71 Chris  Cordier , Stuart  Leach , Daniel  Morton , Adam  Nelson , Catherine  O'Leary-Steele , Stuart  Warriner and Thomas  Woodhall , "An efficient method for synthesising unsymmetrical silaketals: substrates for ring-closing, including macrocycle-closing, metathesis", Org. Biomol. Chem. 2008, 6, 1734-1737
Keywords: "Diversity-oriented synthesis"

70 Chris  Cordier , Daniel  Morton , Sarah  Murrison , Adam  Nelson and Catherine  O'Leary-Steele , "Natural products as an inspiration in the diversity-oriented synthesis of bioactive compound libraries", Nat. Prod. Rep. 2008, , 719-737
Keywords: "Chemical Genetics" "Diversity-oriented synthesis"

69 Chris  Cordier , Stuart  Leach , Gordon  McKiernan , Daniel  Morton , Adam  Nelson and Stuart  Warriner , "A fluorous-tagged linker from which small molecules are released by ring-closing metathesis", J. Org. Chem. 2008, 73, 2752-2759
Keywords: "Diversity-oriented synthesis"

66 Chris  Cordier , Stuart  Leach and Adam  Nelson , "1,3-Dioxetanes and 1,3-Dioxolanes", Science of Synthesis ed. S. Warriner, 2007, 29, 407-486

56 Chris  Cordier and Adam  Nelson , "Reaching the target: small molecules aim to probe barrier quality", ChemBioChem , 6, 1953-1955
Open Access Version - provided courtesy of John Wiley and Sons
Keywords: "Chemical Genetics"

Research areas

Chemical Genetics

Diversity-oriented synthesis

Stereochemically diverse libraries