James  Firth



James graduated from the University of Edinburgh in 2005 with a first class MChem degree in Medicinal and Biological chemistry. In his final year he undertook a Masters project, supervised by Dr. Hon Wai Lam, on the synthesis of 4-hydroxypiperidin-2-ones via a Cu(I)-catalyzed reductive aldol cyclization. After graduation, James briefly joined Evotec before moving to the medicinal chemistry group at Cancer Research Technology. He then moved to York in 2010, engaging in a PhD under the supervision of Prof. Peter O’Brien, working on the asymmetric lithiation of piperazines.

In April 2014, James joined the Nelson group as a Postdoctoral Research Associate. He was developing new routes to innovative libraries as part of the EU's €196M IMI project, the European Lead Factory.

Publications with Professor Nelson:

123 Philip  Craven , James  Firth , Matthew  Lilburn, Steve  Marsden , Adam  Nelson and Axel  Pahl, "A Biosynthesis-Inspired Approach to over Twenty Diverse Natural Product-Like Scaffolds", Chem. Commun. 2016, 52, 9837-9840
Keywords: "Diversity-oriented synthesis"

114 James  Firth , Richard  Foster , Rachel  Guilleux, Tuomo  Kalliokoski, Steve  Marsden , Remy  Morgantin , Adam  Nelson , Stuart  Warriner and Rong  Zhang , "Exploitation of the Ugi-Joulliť reaction in the synthesis of libraries of drug-like bicyclic hydantoins", Synthesis 2015, , 2391-2406
Keywords: "Diversity-oriented synthesis"

Research areas

Diversity-oriented synthesis

Stereochemically diverse libraries