Prof  Adam  Nelson

A.S.Nelson@leeds.ac.uk

0113 343 6502

Adam Nelson is Professor of Chemical Biology at the University of Leeds, with research interests in synthetic organic chemistry and chemical biology. He obtained a BA in Natural Sciences from Churchill College, University of Cambridge in 1993, and his PhD (under the supervisor of Dr Stuart Warren) in Synthetic Organic Chemistry, also from Cambridge, in 1996. He undertook postdoctoral research with Prof. E. J. Thomas at the University of Manchester before joining the academic staff at the University of Leeds in 1998.  He was the Director of the Astbury Centre for Structural Molecular Biology (2009-2011).  He currently leads on developing industrial links with the Astbury Centre for Structural Molecular Biology.  His CV is shown below:

Awards and Scholarships
RSC Corday-Morgan Medal (2007)
AstraZeneca Academic Award (2005)
EPSRC Advanced Research Fellowship (2004-2009)
Pfizer Academic Award (2002)
RSC Meldola Medal (2001)
Scholarship, Churchill College, Cambridge (1991-1993)

Grants and awards
Major grants (>£50k) from research councils and charities
1.         “Strategies for asymmetric synthesis: sequential and parallel kinetic resolutions”, Grant to an institution, Leverhulme Trust, June 1999-May 2001, £55 220.
2.         “Phase transfer catalysts with a chiral anion: asymmetric reactions of cations”, EPSRC fast stream project studentship, October 1999-September 2002, total budget: £52 000.
3.          “Forced evolution of Class II aldolases: New reagents for organic synthesis”, BBSRC grant, October 1999-September 2002, £165 257.
          Principal investigator: Dr. Alan Berry, School of Biochemistry and Molecular Biology, University of Leeds.                                                                                             
4.           “A fluorimeter to underpin research in the School of Chemistry”, EPSRC, January 2001-December 2003, £135 847.
Principal investigator: Professor Godfrey Beddard, School of Chemistry, University of Leeds
Other investigators: Richard Bushby, Neville Boden, Richard Ansell, Malcolm Halcrow
5.          “Regioselective synthesis of indolocarbazole alkaloids”, EPSRC project studentship, October 2000-September 2003, £53 341.
6.          “A library of chimeric aminoglycosides”, BBSRC, November 2001-October 2004,   £172 264.
Principal investigator: ASN
Co-investigator: Professor Peter Stockley, Astbury Centre, University of Leeds
7.           “Directed evolution of sialic acid aldolases: a combinatorial approach to sialic acid mimetics”, BBSRC, December 2001-November 2004, £191, 000.
Principal investigator: Dr. Alan Berry, School of Biochemistry and Molecular Biology, University of Leeds
8.          “Formation of a Centre for Biomolecular Interactions”, Wellcome JIF grant, October 2001-September 2004, £7,500,000.
Principal investigator: Professor Peter Stockley, Astbury Centre, University of Leeds
Other investigators: Peter Henderson, Alex Markham, Sheena Radford, John Trinick, John Findlay, Steve Homans, Ron Grigg, Peter Johnson
9.          “Chemical Biology of a library of apramycin analogues”, Wellcome Trust 4-year PhD studentship, October 2001-October 2004.
Co-investigator: Professor Peter Stockley, Astbury Centre, University of Leeds
10.       “Targetting the thiostrepton binding site of the ribosome”, Wellcome Trust 4-year PhD studentship, October 2002-September 2005.
Co-investigator: Professor Peter Stockley, Astbury Centre, University of Leeds
11.       “Controlling gene expression via small molecular weight effectors”, BBSRC, April 2003-October 2004, £104 147.
Principal investigator: Professor Peter Stockley, Astbury Centre, University of Leeds
12.       “A total synthesis of Hemibrevetoxin B: Desymmetrisation of centrosymmetric molecules by asymmetric C-C bond formation”, EPSRC, January 2004-January 2006, £120 265.
13.       “Advanced Fellowship: Diversity oriented synthesis and chemical biology of unnatural products”, EPSRC, October 2004-September 2009, £290, 000.
14.      “Diversity oriented synthesis of unnatural products”, EPSRC, December 2004-November 2007, £210,939.
         Co-investigator: Professor Peter Stockley, Astbury Centre, University of Leeds
15.      “Libraries of diverse natural product-like compounds”, Wellcome Trust 4-year PhD studentship, October 2004-September 2007.
         Co-investigator: Dr Stuart Warriner, School of Chemistry, University of Leeds
16.    “Glycogen synthase kinase: a critical regulator of stem cell self-renewal?”, BBSRC, March 2005-February 2008, £120 000.
         Principal investigator: ASN
         Linked to grant with principal investigator, Prof. Melanie Welham, University of Bath, £175 000.
17. "Developing applications of allosteric aptamers and bespoke riboswitches”, BBSRC, January 2005-December 2007, £210 000
Principal investigator: Professor Peter Stockley, Astbury Centre, University of Leeds
Co-investigator: Dr Ian Hope, Faculty of Biological Sciences, University of Leeds
18.      “Templated synthesis of bivalent ligands by protein dimers”, Wellcome Trust 4-year PhD studentship, October 2005-September 2008.
       Co-investigators: Dr Stuart Warriner and Dr Bruce Turnbull, School of Chemistry, University of Leeds.
19.   “New bicatalytic chemistry for the synthesis of bioactive molecules”, EPSRC project studentship, £95 000 (FEC: £105 000), October 2006-September 2009.
       Co-investigator: Dr Alan Berry, Astbury Centre, University of Leeds
20.  “Enzymic synthesis of complex carbohydrates using evolved enzymes”, BBSRC, £549k (FEC: £686k) , January 2007 – December 2009.               
       Principal investigator: Dr. Alan Berry, Astbury Centre, University of Leeds
21.   “The Linchpin Approach in the Array Synthesis of Bioactive Ligand Scaffolds”, EPSRC £599k (FEC: £700k) plus £329k contribution (£22k cash) from GSK, March 2007 – September 2011
       Principal investigator: Dr. Steve Marsden, University of Leeds
22.   “UK-China Virtual Laboratory for the Systems Biology of Membrane Function”, BBSRC China Partnering Award, £25k, April 2007 – March 2009. Principal investigator: Prof. Steve Baldwin; Co-investigators: Profs D. Beech, J. Deuchars, S. Phillips, P. Henderson, B. Robertson and A. Turner and Drs D. Donnelly, N. Cohen, J. Lippiat and L.-H. Jiang
23.   “MULTISCAFFOLD: A new strategy for the diversity-oriented synthesis of alkaloid-like compounds for chemical genetic studies”, Marie Curie Incoming Fellowship, EU, £153k (€250k), June 2008-May 2010        
       Fellow: Dr Sushil Maurya
24.    “Probing the extraordinary bioactivity of macrocyclic natural products: privileged motifs or biosynthetic artefacts?”, EPSRC £430k (FEC: £538k), July 2008-June 2012
         Co-investigators: Dr Paul Ko Ferrigno, LIMM, and Dr Stuart Warriner, School of Chemistry, University of Leeds
25.    “Small molecule inhibitors of RSV”, Wellcome Trust 4-year PhD studentship, £140k, Oct 2008-Sep 2012
         Co-investigators: Dr John Barr and Dr Julian Hiscox, Astbury Centre for Structural Molecular Biology
26.    “Synthesis of diverse small molecule scaffolds”, AstraZeneca, £155k, Oct 2010-Sep 2012
         Co-investigator: Dr Sri Sridharan, School of Chemistry, University of Leeds
27.    “Protein engineering of polyketide and polyether synthesizing enzymes”, Wellcome Trust 4-year PhD studentship, £140k, Oct 2010-Sep 2014.
         PI: Professor Alan Berry,
28.    “Realising lead-oriented synthesis”, EPSRC, £550k, Apr 2012 – Mar 2015
  Co-investigator: Professor Steve Marsden, School of CHemistry, University of Leeds
29.    CHEM21: Chemical Manufacturing Methods for the 21st Century Pharmaceutical Industry”, EU IMI, Leeds share: €1.25M (of €10M)
         Consortium leader: Professor Nick Turner (University of Manchester); Leeds PI: Professor John Blacker; Co-investigators: Professors Steve Marsden, Chris Rayner, Peter Johnson and Alan Berry
30. The European Lead Factory”, EU IMI, Leeds share: €1.6M (of €80M)
         Co-investigators at Leeds: Professors Steve Marsden and Richard Foster
31. "Exploiting the distinctive catalysis of chemically-modified enzymes", BBSRC, £480k, PI: Prof. Alan Berry.
32. "Integrated computational and synthetic tools to drive the discovery of orthosteric protein-protein interaction inhibitors”, EPSRC, £2.7M, Feb 2016-Jan 2021.  Principal investigator: Professor Andrew Wilson, co-Is: Dr Thomas Edwards, Dr Gail Bartlett, Professor Dek Woolfson and Dr Richard Sessions
33.  "Autonomous Discovery of Functional Small Molecules”, EPSRC, £1.2M, Oct 2016-Sep 2021
34.
“The realisation of fragment-oriented synthesis”, EPSRC, £550k, April 2017-March 2020.  Principal investigator: Professor Steve Marsden

Invited lectures at international meetings:

RSC 18th Lakeland Heterocyclic symposium, Grasmere, UK (2003)

RSC 16th International Symposium on Synthesis in Organic Chemistry, Churchill College, Cambridge (2003)

First USA-UK Organic Synthesis Workshop (2004)

European Symposium of Organic Chemistry 14, Helsinki, Finland (2005)

Enzymology in Como, Como, Italy (2006)

Gordon Research conference in Biocatalysis, Rhode Island, USA (2008)

ERA-Chemistry Flash Conference “Carbohydrates at the Interfaces of Biology, Medicine and Materials Science”, Killarney, Ireland (2008)

42nd IUPAC Congress (associated with Corday-Morgan award) (2009)

ACS National meeting in “Macrocylisation as a Tool in Drug Discovery” session (2009)

EuCheMS 2010, Nuremburg, Germany (2010)

MedChem Europe, Munich, Germany (2010)

European Chemical Biology Symposium (2010)

PACIFICHEM conference of Pacific Rim countries (2010, declined)

European Symposium of Organic Chemistry 17, Crete, Greece (2011)

South African Chemistry Congress, Durban (2011, declined)

Asian Chemical Congress, Bangkok, Thailand (2011)

RSC Symposium on Drug Discovery, Singapore (2011)

MedChem Europe, Munich, Germany (2013, delegated)

Gordon Conference on High-Throughput Chemistry and Biology, New Hampshire, US (2013)

22nd International Isotopes Symposium, Cambridge, UK (2013)

10th German Chemical Biology meeting, Frankfurt, Germany (2015)

Drug Discovery satellite meeting, Tetrahedron symposium, Berlin, Germany (2015)

Medicinal Chemistry meeting, Royal Netherlands Chemical Society, Utrecht, Netherlands (2016)

52nd International Conference on Medicinal Chemistry, Caen, France (2016)

6th Pharmaceutical Sciences World Congress, Stockholm, Sweden (2017)

Nordic Chemical Biology Meeting, Copenhagen, Denmark (2017)