George  Burslem

cmgb@leeds.ac.uk

01133436436

George graduated from the University of Bristol with a first class MChem degree. He spent the third year of his degree working in the Chemical Biology group at Pfizer in Sandwich. George’s final year project was carried out under the supervision of Professor Tom Simpson FRS FRSE on the synthesis of probes for kinase identification.  He also undertook a summer placement at the Pfizer site in Groton, CT, USA during his degree.
George was funded by the EPSRC and AstraZeneca to work on a project in collaboration with Dr Andy Wilson, Dr Thomas Edwards and Dr Stuart Warriner concerning the inhibition of protein-protein interactions.
He moved to postdoctoral position at Yale with Professor Craig Crews.

Publications with Professor Nelson:

130 George   Burslem , Thomas  Edwards , Hannah  Kyle , Adam  Nelson and Andrew  Wilson , "Hypoxia inducible factor (HIF) as a model for studying inhibition of protein-protein interactions", Chem. Sci. 2017, 8, 4188-4202
Keywords: "Chemical Genetics"

120 Alex   Breeze , George   Burslem , Thomas  Edwards , Hannah  Kyle , Adam  Nelson , P  Prabhakaran, Stuart  Warriner and Andrew  Wilson , "Synthesis of highly functionalised oligobenzamide proteomimetic foldamers by late stage introduction of sensitive groups", Org. Biomol. Chem. 2016, 14, 3782-3786
Keywords: "Chemical Genetics"

119 Alex   Breeze , George   Burslem , Thomas  Edwards , Hannah  Kyle , Adam  Nelson , Stuart  Warriner and Andrew  Wilson , "Towards ‘bionic’ proteins: replacement of continuous sequences from HIF-1alpha with proteomimetics to create functional p300 binding HIF-1alpha mimics", Chem. Commun. 2016, 52, 5421-5424
Keywords: "Chemical Genetics"

113 Alex   Breeze , George   Burslem , Thomas  Edwards , Hannah  Kyle , Adam  Nelson , Jonathan  Stott, Darren  Tomlinson , Stuart  Warriner , Kate  Wickson and Andrew  Wilson , "Exploration of the HIF-1alpha/p300 binding interface using peptide and adhiron phage display technologies to locate binding hot-spots for inhibitor development", Mol. Biosys. 2015, 11, 2738-2749
Keywords: "Chemical Genetics"

110 Ololade  Adeniji, George   Burslem , Ignacio  Colomer Utrera , Philip  Craven , Richard  Foster , Tuomo  Kalliokoski, Steve  Marsden , Adam  Nelson , Martin  Rasmussen and Anthony  Willaume, "Aminomethylhydroxylation of alkenes: Exploitation in the synthesis of scaffolds for small molecule libraries", Bioorg. Med. Chem. 2015, , in press
Keywords: "Diversity-oriented synthesis"

105 Alex   Breeze , George   Burslem , Thomas  Edwards , Hannah  Kyle , Adam  Nelson , Stuart  Warriner and Andrew  Wilson , "Small Molecule Proteomimetic Inhibitors of the HIF-1alpha/p300 Protein-Protein Interaction", ChemBioChem 2014, 14, 1083-1087
Keywords: "Chemical Genetics"

104 George   Burslem , Andrew  Grant , Tom   James , Paul  MacLellan , Adam  Nelson , Iain  Simpson , Sri  Sridharan and Stuart  Warriner , "A modular lead-oriented synthesis of diverse piperazine, 1,4-diazepane and 1,5-diazocane scaffolds", Org. Biomol. Chem. 2014, 12, 2584-2591
Keywords: "Diversity-oriented synthesis"

Research areas

Stereochemically diverse libraries