Hannah  Kyle

bs07hk@leeds.ac.uk

Hannah Kyle graduated in Pharmacology (Industrial option) from the University of Leeds in 2011. Her industrial placement was spent at the Pfizer research laboratories in Sandwich, and focused on the formulation and analysis of powder products. On return to the University, her final year project was conducted with Prof. Chopra and focused on the determination of the mode of action of novel antibacterial agents.
Hannah was funded by the EPSRC and AstraZeneca to work on a project in collaboration with Dr Andy Wilson, Dr Thomas Edwards and Dr Stuart Warriner concerning the inhibition of protein-protein interactions.  Her project focused on the structural biology and biophysical characterisation of protein-protein interactions.
Hannah moved to a position as a biophysicist with Avacta.

Publications with Professor Nelson:

130 George   Burslem , Thomas  Edwards , Hannah  Kyle , Adam  Nelson and Andrew  Wilson , "Hypoxia inducible factor (HIF) as a model for studying inhibition of protein-protein interactions", Chem. Sci. 2017, 8, 4188-4202
Keywords: "Chemical Genetics"

120 Alex   Breeze , George   Burslem , Thomas  Edwards , Hannah  Kyle , Adam  Nelson , P  Prabhakaran, Stuart  Warriner and Andrew  Wilson , "Synthesis of highly functionalised oligobenzamide proteomimetic foldamers by late stage introduction of sensitive groups", Org. Biomol. Chem. 2016, 14, 3782-3786
Keywords: "Chemical Genetics"

119 Alex   Breeze , George   Burslem , Thomas  Edwards , Hannah  Kyle , Adam  Nelson , Stuart  Warriner and Andrew  Wilson , "Towards ‘bionic’ proteins: replacement of continuous sequences from HIF-1alpha with proteomimetics to create functional p300 binding HIF-1alpha mimics", Chem. Commun. 2016, 52, 5421-5424
Keywords: "Chemical Genetics"

113 Alex   Breeze , George   Burslem , Thomas  Edwards , Hannah  Kyle , Adam  Nelson , Jonathan  Stott, Darren  Tomlinson , Stuart  Warriner , Kate  Wickson and Andrew  Wilson , "Exploration of the HIF-1alpha/p300 binding interface using peptide and adhiron phage display technologies to locate binding hot-spots for inhibitor development", Mol. Biosys. 2015, 11, 2738-2749
Keywords: "Chemical Genetics"

105 Alex   Breeze , George   Burslem , Thomas  Edwards , Hannah  Kyle , Adam  Nelson , Stuart  Warriner and Andrew  Wilson , "Small Molecule Proteomimetic Inhibitors of the HIF-1alpha/p300 Protein-Protein Interaction", ChemBioChem 2014, 14, 1083-1087
Keywords: "Chemical Genetics"