George  Karageorgis

cm10gk@leeds.ac.uk

36436

 

George Karageorgis graduated from the Department of Chemistry of the Aristotle University of Thessaloniki in 2010. His final year project concerned the importance of disulfide bonds for the reactivity and structure of the SRPK1 kinase.
Before joining the group as a PhD student, he obtained a Distinction on the University of Leeds’s Chemical Biology MSc. His MSc project was conducted under the supervision of Prof. A. Nelson and Dr. S. Warriner, and concerned the design and synthesis of diverse ligands that may target the hRSV Fusion protein.  George’s PhD was supported by a University Research Scholarship and was concerned with the use of diversity-oriented synthesis to target the androgen receptor.  George spent few months working in the group as a postdoctoral researcher before working with Professor Herbert Waldmann at the Max Planck Institute for Molecular Physiology in Dortmund.  George returned to the Nelson group in 2018 as a postdoctoral researcher focused on the realisation of activity-directed synthesis.

Publications with Professor Nelson:

137 Anthony  Aimon , Mark  Dow , Tuomo  Kalliokoski, George  Karageorgis , Steve  Marsden , Remy  Morgantin , Adam  Nelson and Didier  Roche, "Translation of innovative chemistry into screening libraries: an exemplar partnership from the European Lead Factory", Drug Discovery Today 2018, 23, 1578-1583
Keywords: "Chemical Genetics" "Diversity-oriented synthesis"

135 Anthony  Aimon , Philip  Craven , Mark  Dow , Andy  Eatherton, Daniel  Foley , Tuomo  Kalliokoski, George  Karageorgis , Hugues  Lemoine, Steve  Marsden , Jacob  Masters , Remy  Morgantin , Martin  Ohsten, Didier  Roche , Nicolas  Ruiz-Llamas and Anthony  Willaume, "Realisation of small molecule libraries based on frameworks distantly related to natural products", Org. Biomol. Chem. 2018, 16, 3160-3167
Keywords: "Diversity-oriented synthesis"

116 Anthony  Aimon , Mark  Dow , George  Karageorgis , Adam  Nelson and Stuart  Warriner , "Activity-directed Synthesis with Intermolecular Reactions: Development of a Fragment into a Range of Androgen Receptor Agonists", Angew. Chem. Int. Ed. 2015, 54, 13538-13544
Keywords: "Diversity-oriented synthesis"

107 George  Karageorgis , Adam  Nelson and Stuart  Warriner , "Efficient discovery of bioactive scaffolds by activity-directed synthesis", Nature Chem. 2014, 6, 872-876
Keywords: "Diversity-oriented synthesis"

Research areas

Diversity-oriented synthesis

Stereochemically diverse libraries