Tom  James

t.o.james@leeds.ac.uk

0113 343 36436

Tom graduated from the University of Leeds in 2009 with a first class MChem degree. He spent the third year of his degree on placement with Hoffmann-La Roche at their site in Basel, Switzerland. Tom's final year project was conducted under the supervision of Prof. A. Nelson investigating synthesis of diverse heterocycles using cascade metathesis.  Tom's PhD was supported by the EPSRC and is concerned with the development of new strategies for preparing skeletally-diverse small molecules.


Following his PhD, Tom moved to a postdoctoral position with Prof. Ben List at the Max Planck Institute in Mulheim.  Following a position at Peakdale Molecular, he returned to Leeds as a postdoctoral researcher focusing on new approached to discovery small molecule inhibitors of protein-protein interactions.

 

Publications with Professor Nelson:

104 George   Burslem , Andrew  Grant , Tom   James , Paul  MacLellan , Adam  Nelson , Iain  Simpson , Sri  Sridharan and Stuart  Warriner , "A modular lead-oriented synthesis of diverse piperazine, 1,4-diazepane and 1,5-diazocane scaffolds", Org. Biomol. Chem. 2014, 12, 2584-2591
Keywords: "Diversity-oriented synthesis"

100 Andrew  Grant , Tom   James , Adam  Nelson , Iain  Simpson and Sri  Sridharan , "Modular, gold-catalysed approach to the synthesis of lead-like piperazine scaffolds", Org. Lett. 2013, 15, 6094-6097
Keywords: "Diversity-oriented synthesis"

89 Mark  Dow , Martin  Fisher , Tom   James , Francesco  Marchetti and Adam  Nelson , "Towards the systematic exploration of chemical space", Org. Biol. Chem. 2012, , in press
Keywords: "Chemical Genetics" "Diversity-oriented synthesis"

81 Jerome  Hayes, Tom   James , Tom  Lanyon-Hogg , Stuart  Leach , Adam  Nelson , Catherine  O'Leary-Steele and Palle  Pedersen , "Synthesis of Small Molecules with High Scaffold Diversity: Exploitation of Metathesis Cascades in Combination with Inter- and Intramolecular Diels-Alder Reactions", Chem. Eur. J. 2010, , 9563-9671
Keywords: "Diversity-oriented synthesis"

Research areas

Chemical Genetics

Diversity-oriented synthesis