Dr  Mark  Dow

M.J.Dow@leeds.ac.uk

0113 343 6436

Mark graduated with a first class MChem degree from the University of Leicester in 2008. Mark spent the third year of his undergraduate degree on placement with AstraZeneca at their Charnwood site.  His final year project was conducted under the supervision of Dr Sandeep Handa, and focused on the synthesis of novel Epibatidine analogues.

Mark's PhD was supported by the EPSRC, and involves collaboration with AstraZeneca.  His project concerned the synthesis of natural product-like macrocycles.  Mark continued at Leeds as a postdoctoral researcher: he was responsible for coordinating chemistry activities within the European Lead Factory.  He moved to a position as a process chemist at AstraZeneca.

Publications with Professor Nelson:

137 Anthony  Aimon , Mark  Dow , Tuomo  Kalliokoski, George  Karageorgis , Steve  Marsden , Remy  Morgantin , Adam  Nelson and Didier  Roche, "Translation of innovative chemistry into screening libraries: an exemplar partnership from the European Lead Factory", Drug Discovery Today 2018, 23, 1578-1583
Keywords: "Chemical Genetics" "Diversity-oriented synthesis"

135 Anthony  Aimon , Philip  Craven , Mark  Dow , Andy  Eatherton, Daniel  Foley , Tuomo  Kalliokoski, George  Karageorgis , Hugues  Lemoine, Steve  Marsden , Jacob  Masters , Remy  Morgantin , Martin  Ohsten, Didier  Roche , Nicolas  Ruiz-Llamas and Anthony  Willaume, "Realisation of small molecule libraries based on frameworks distantly related to natural products", Org. Biomol. Chem. 2018, 16, 3160-3167
Keywords: "Diversity-oriented synthesis"

129 Katherine  Abrahams, Del  Besra, Mark  Dow , Adam  Nelson , Luis  Vaz and Stuart  Warriner , "Modular Synthesis of Diverse Natural Product-like Macrocycles: Discovery of Hits with Antimycobacterial Activity", Chem. Eur. J. 2017, 23, 7207-7211
Keywords: "Chemical Genetics" "Diversity-oriented synthesis"

116 Anthony  Aimon , Mark  Dow , George  Karageorgis , Adam  Nelson and Stuart  Warriner , "Activity-directed Synthesis with Intermolecular Reactions: Development of a Fragment into a Range of Androgen Receptor Agonists", Angew. Chem. Int. Ed. 2015, 54, 13538-13544
Keywords: "Diversity-oriented synthesis"

109 Anthony  Aimon , Philip  Craven , Mark  Dow , Nicolas  Fleury-Bregeot, Richard  Foster , Rachel  Guilleux, Tuomo  Kalliokoski, Steve  Marsden , Remy  Morgantin , Adam  Nelson and Didier  Roche , "Design, synthesis and decoration of molecular scaffolds for exploitation in the production of alkaloid-like libraries", Bioorg. Med. Chem. 2015, , doi:10.1016/j.bmc.2014.12.048
Keywords: "Diversity-oriented synthesis"

108 Amanda  Campbell , Ian  Churcher, Richard  Doveston , Mark  Dow , Daniel  Foley , David  House , Ho Yin (John)  Li , Steve  Marsden , Adam  Nelson and Paolo  Tosatti , "A unified lead-oriented synthesis of over fifty molecular scaffolds", Org. Biomol. Chem. 2015, 13, 859-865
Keywords: "Diversity-oriented synthesis"

96 Mark  Dow , Sushil  Maurya , Adam  Nelson and Stuart  Warriner , "Synthesis of skeletally diverse alkaloid-like molecules: exploitation of metathesis substrates assembled from triplets of building blocks", Beil. J. Org. Chem. 2013, 9, 775-785
Keywords: "Diversity-oriented synthesis"

95 Mark  Dow , Francesco  Marchetti and Adam  Nelson , "Diversity-oriented synthesis of natural product-like libraries", Diversity-oriented synthesis, ed. A. Trabocchi 2013, , chapter 9, pp 291-323
Keywords: "Diversity-oriented synthesis"

89 Mark  Dow , Martin  Fisher , Tom   James , Francesco  Marchetti and Adam  Nelson , "Towards the systematic exploration of chemical space", Org. Biol. Chem. 2012, , in press
Keywords: "Chemical Genetics" "Diversity-oriented synthesis"

Research areas

Chemical Genetics

Diversity-oriented synthesis