Dr  Paolo  Tosatti

 

 

Paolo graduated in chemistry with honours from the University of Genoa in 2007 which involved a final year project on the diversity and complexity-oriented synthesis of heterocyclic scaffolds via multicomponent reactions, under the supervision of Prof. G. Guanti.

Paolo was supported by a grant from EPSRC (£600k) held by Steve Marsden and Adam Nelson.  His project involved the development of new methods for the synthesis of arrays of potentially bioactive molecules, and involved major collaboration with GSK.  This grant enabled the synthesis of libraries of bioactive molecules, an area which is key to the development of Chemical Genetics at the University of Leeds. 

Paolo moved on to a postdoctoral position with Professor Andreas Pfaltz at the University of Basel.  He currently holds a position as a research scientist at Novartis (Basel).

Publications with Professor Nelson:

108 Amanda  Campbell , Ian  Churcher, Richard  Doveston , Mark  Dow , Daniel  Foley , David  House , Ho Yin (John)  Li , Steve  Marsden , Adam  Nelson and Paolo  Tosatti , "A unified lead-oriented synthesis of over fifty molecular scaffolds", Org. Biomol. Chem. 2015, 13, 859-865
Keywords: "Diversity-oriented synthesis"

91 Steve  Marsden , Adam  Nelson and Paolo  Tosatti , "Recent advances and applications of iridium-catalysed asymmetric allylic substitution", Org. Biomol. Chem 2012, 10, 3157-3163
Keywords: "Stereochemically diverse libraries"

88 Amanda  Campbell , David  House , Steve  Marsden , Adam  Nelson and Paolo  Tosatti , "Control in Sequential Asymmetric Allylic Substitution: Stereodivergent Access to N,N-Diprotected Unnatural Amino Acids", J. Org. Chem. 2011, 76, 5495-5501
Keywords: "Diversity-oriented synthesis"

84 Amanda  Campbell , Joachim  Horn , David  House , Adam  Nelson and Paolo  Tosatti , "Iridium-Catalyzed Asymmetric Allylic Amination with Polar Amines: Access to Building Blocks with Lead-Like Molecular Properties", Adv. Synth. Cat. 2010, 352, 3153-3157
Keywords: "Diversity-oriented synthesis"

Research areas

Chemical Genetics

Diversity-oriented synthesis