Prof  Steve  Marsden

s.p.marsden@leeds.ac.uk

0113 343 6425

Steve Marsden and Adam Nelson collaborate with Dr David House and Dr Gordon Weingarten (GSK) on a major project to develop new methods for the synthesis of arrays of ligands.  The four and a half-year project is jointly funded by EPSRC and GSK, and involves one postdoctoral research and two PhD students.  The development of new methodology for preparing putative bioactives is key to the development of Chemical Genetics at the University of Leeds.  Find out more about Steve's research here.

Publications with Professor Nelson:

137 Anthony  Aimon , Mark  Dow , Tuomo  Kalliokoski, George  Karageorgis , Steve  Marsden , Remy  Morgantin , Adam  Nelson and Didier  Roche, "Translation of innovative chemistry into screening libraries: an exemplar partnership from the European Lead Factory", Drug Discovery Today 2018, 23, 1578-1583
Keywords: "Chemical Genetics" "Diversity-oriented synthesis"

135 Anthony  Aimon , Philip  Craven , Mark  Dow , Andy  Eatherton, Daniel  Foley , Tuomo  Kalliokoski, George  Karageorgis , Hugues  Lemoine, Steve  Marsden , Jacob  Masters , Remy  Morgantin , Martin  Ohsten, Didier  Roche , Nicolas  Ruiz-Llamas and Anthony  Willaume, "Realisation of small molecule libraries based on frameworks distantly related to natural products", Org. Biomol. Chem. 2018, 16, 3160-3167
Keywords: "Diversity-oriented synthesis"

134 Haitham  Hassan , Steve  Marsden and Adam  Nelson , "Design and synthesis of a fragment set based on twisted bicyclic lactams", Bioorg. Med. Chem. Lett. 2018, 26, 3030-3033
Keywords: "Diversity-oriented synthesis"

133 Anthony  Aimon , Ian  Churcher, Patrick  Collins, Philip  Craven , Richard  Doveston , Daniel  Foley , Steve  Marsden , Adam  Nelson , Romain  Talon and Frank  von Delft, "Synthesis and Demonstration of the Biological Relevance of sp3-rich Scaffolds Distantly Related to Natural Product Frameworks", Chem. Eur. J. 2017, 23, 15227-15232
Keywords: "Diversity-oriented synthesis"

1 Anthony  Aimon , Patrick  Collins, Philip  Craven , Richard  Doveston , Daniel  Foley , Steve  Marsden , Adam  Nelson , Romain  Talon and Frank  von Delft, "Synthesis and Demonstration of the Biological Relevance of sp3-rich Scaffolds Distantly Related to Natural Product Frameworks", Chemistry - A European Journal 2017, 23, 15227–15232
Keywords: "Chemical Genetics" "Diversity-oriented synthesis"

124 Daniel  Foley , Steve  Marsden and Adam  Nelson , "Evaluating New Chemistry to Drive Molecular Discovery: Fit for Purpose?", Angew. Chem. Int Ed. 2016, 55, 13650-13657
Keywords: "Diversity-oriented synthesis"

123 Philip  Craven , James  Firth , Matthew  Lilburn, Steve  Marsden , Adam  Nelson and Axel  Pahl, "A Biosynthesis-Inspired Approach to over Twenty Diverse Natural Product-Like Scaffolds", Chem. Commun. 2016, 52, 9837-9840
Keywords: "Diversity-oriented synthesis"

122 Ian  Churcher, Ignacio  Colomer Utrera , Philip  Craven , Richard  Doveston , Christopher  Empson, Steve  Marsden , Adam  Nelson and Zach  Owen, "A divergent synthetic approach to diverse molecular scaffolds: assessment of lead-likeness using LLAMA, an open access computational tool", Chem. Commun. 2016, 52, 5209-5212
Keywords: "Diversity-oriented synthesis"

114 James  Firth , Richard  Foster , Rachel  Guilleux, Tuomo  Kalliokoski, Steve  Marsden , Remy  Morgantin , Adam  Nelson , Stuart  Warriner and Rong  Zhang , "Exploitation of the Ugi-Joullié reaction in the synthesis of libraries of drug-like bicyclic hydantoins", Synthesis 2015, , 2391-2406
Keywords: "Diversity-oriented synthesis"

112 Ian  Churcher, Richard  Doveston , Daniel  Foley , Steve  Marsden and Adam  Nelson , "A systematic approach to diverse, lead-like scaffolds from alpha,alpha-disubstituted amine acids", Chem. Commun. 2015, 51, 11174-11177
Keywords: "Diversity-oriented synthesis"

110 Ololade  Adeniji, George   Burslem , Ignacio  Colomer Utrera , Philip  Craven , Richard  Foster , Tuomo  Kalliokoski, Steve  Marsden , Adam  Nelson , Martin  Rasmussen and Anthony  Willaume, "Aminomethylhydroxylation of alkenes: Exploitation in the synthesis of scaffolds for small molecule libraries", Bioorg. Med. Chem. 2015, , in press
Keywords: "Diversity-oriented synthesis"

109 Anthony  Aimon , Philip  Craven , Mark  Dow , Nicolas  Fleury-Bregeot, Richard  Foster , Rachel  Guilleux, Tuomo  Kalliokoski, Steve  Marsden , Remy  Morgantin , Adam  Nelson and Didier  Roche , "Design, synthesis and decoration of molecular scaffolds for exploitation in the production of alkaloid-like libraries", Bioorg. Med. Chem. 2015, , doi:10.1016/j.bmc.2014.12.048
Keywords: "Diversity-oriented synthesis"

108 Amanda  Campbell , Ian  Churcher, Richard  Doveston , Mark  Dow , Daniel  Foley , David  House , Ho Yin (John)  Li , Steve  Marsden , Adam  Nelson and Paolo  Tosatti , "A unified lead-oriented synthesis of over fifty molecular scaffolds", Org. Biomol. Chem. 2015, 13, 859-865
Keywords: "Diversity-oriented synthesis"

106 Amanda  Campbell , Joachim  Horn , David  House , Ho Yin (John)  Li , Steve  Marsden and Adam  Nelson , "A convergent rhodium-catalysed asymmetric synthesis of tetrahydroquinolines", Chem. Commun. 2014, 50, 10222-10224
Keywords: "Diversity-oriented synthesis"

98 Richard  Doveston , Steve  Marsden and Adam  Nelson , "Towards the realisation of lead-oriented synthesis", Drug Discov. Today 2014, 7, 813-819
Keywords: "Diversity-oriented synthesis"

91 Steve  Marsden , Adam  Nelson and Paolo  Tosatti , "Recent advances and applications of iridium-catalysed asymmetric allylic substitution", Org. Biomol. Chem 2012, 10, 3157-3163
Keywords: "Stereochemically diverse libraries"

88 Amanda  Campbell , David  House , Steve  Marsden , Adam  Nelson and Paolo  Tosatti , "Control in Sequential Asymmetric Allylic Substitution: Stereodivergent Access to N,N-Diprotected Unnatural Amino Acids", J. Org. Chem. 2011, 76, 5495-5501
Keywords: "Diversity-oriented synthesis"

79 Amanda  Campbell , Joachim  Horn , David  House , Ho Yin (John)  Li , Steve  Marsden , Adam  Nelson , Rachel  Shearer and Gordon  Weingarten , "Convergent synthesis of dihydroquinolones from o-aminoarylboronates", Tetrahedron 2009, 65, 9002-9007
Keywords: "Diversity-oriented synthesis"

72 Joachim  Horn , David  House , Steve  Marsden , Adam  Nelson and Gordon  Weingarten , "Convergent, Regiospecific Synthesis of Quinolines from o-Aminophenylboronates ", Org. Lett. 2008, 10, 4117-4120
Keywords: "Diversity-oriented synthesis"

Research areas

Chemical Genetics

Diversity-oriented synthesis

Stereochemically diverse libraries