Tom  Harman

bms0tah@leeds.ac.uk

36436

Tom graduated from the University of Leeds in 2004 with a BSc (Ind) degree from the Department of Colour and Polymer Chemistry. His final year project was concerned with the use of Azo dyes as metal ion indicators, working under the supervision of Prof. Griffiths.

In 2005, Tom completed the school of Chemistry's Chemical Biology MSc course. His research project involved an investigation into the thermodynamics of inhibiting protein-protein interactions using small molecules, under the supervision of Dr Wilson and Dr Turnbull.

Tom is in the second year of his PhD, under the supervision of Prof. Nelson and Dr Berry. His project will utilise the directed evolution of an aldolase enzyme to create stereochemically diverse libraries of compounds.

Publications with Professor Nelson:

117 Alan  Berry , Adam  Daniels , Tom  Harman , Tomas  Lebl, Keith   Mullholland, Adam  Nelson , Arwen  Pearson, Jennifer  Stockwell , Chi  Trinh , Claire  Windle and Thomas  Woodhall , "Evaluation of fluoropyruvate as nucleophile in reactions catalysed by N-acetyl neuraminic acid lyase variants: scope, limitations and stereoselectivity", Org. Biomol. Chem. 2015, , in press
Keywords: "Directed evolution"

93 Alan  Berry , Tilly  Bingham , Tom  Harman , Angela  Kinnell and Adam  Nelson , "Development of an organo- and enzyme-catalysed one-pot, sequential three-component reaction", Tetrahedron 2012, 68, 7719-7722
Keywords: "Directed evolution"

83 Alan  Berry , Amanda  Bolt , Ivan  Campeotto , Catriona  Dennis, Tom  Harman , Adam  Nelson , Arwen  Pearson and Simon  Phillips, "Structural Insights into Substrate Specificity in Variants of N-Acetylneuraminic Acid Lyase Produced by Directed Evolution", J. Mol. Biol. 2010, 404, 56-69
Keywords: "Directed evolution"

Research areas

Directed evolution

Diversity-oriented synthesis

Stereochemically diverse libraries