Publications

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140 Samuel  Liver , Jacob  Masters and Adam  Nelson , "Function-driven Discovery of Bioactive Small Molecules", Chemical and Biological Synthesis: Enabling Approaches for Understanding Biology 2018, , 138-152
Keywords: "Diversity-oriented synthesis"

139 Adam  Nelson and Nicholas  Westwood, "Synthetic Tools for Elucidating Biological Mechanisms", Chemical and Biological Synthesis: Enabling Approaches for Understanding Biology 2018, , 1-7
Keywords: "Chemical Genetics" "Diversity-oriented synthesis"

138 Adam  Nelson and Nicholas  Westwood, "Chemical and Biological Synthesis: Enabling Approaches for Understanding Biology", Royal Society of Chemistry 2018, ,  ISBN: 978-1-78262-948-1
Keywords: "Chemical Genetics" "Diversity-oriented synthesis"

137 Anthony  Aimon , Mark  Dow , Tuomo  Kalliokoski, George  Karageorgis , Steve  Marsden , Remy  Morgantin , Adam  Nelson and Didier  Roche, "Translation of innovative chemistry into screening libraries: an exemplar partnership from the European Lead Factory", Drug Discovery Today 2018, 23, 1578-1583
Keywords: "Chemical Genetics" "Diversity-oriented synthesis"

136 Shiao  Chow , Samuel  Liver and Adam  Nelson , "Streamlining bioactive molecular discovery through integration and automation", Nat. Rev. Chem. 2018, 2, 174-183
Keywords: "Diversity-oriented synthesis"

135 Anthony  Aimon , Philip  Craven , Mark  Dow , Andy  Eatherton, Daniel  Foley , Tuomo  Kalliokoski, George  Karageorgis , Hugues  Lemoine, Steve  Marsden , Jacob  Masters , Remy  Morgantin , Martin  Ohsten, Didier  Roche , Nicolas  Ruiz-Llamas and Anthony  Willaume, "Realisation of small molecule libraries based on frameworks distantly related to natural products", Org. Biomol. Chem. 2018, 16, 3160-3167
Keywords: "Diversity-oriented synthesis"

134 Haitham  Hassan , Steve  Marsden and Adam  Nelson , "Design and synthesis of a fragment set based on twisted bicyclic lactams", Bioorg. Med. Chem. Lett. 2018, 26, 3030-3033
Keywords: "Diversity-oriented synthesis"

133 Anthony  Aimon , Ian  Churcher, Patrick  Collins, Philip  Craven , Richard  Doveston , Daniel  Foley , Steve  Marsden , Adam  Nelson , Romain  Talon and Frank  von Delft, "Synthesis and Demonstration of the Biological Relevance of sp3-rich Scaffolds Distantly Related to Natural Product Frameworks", Chem. Eur. J. 2017, 23, 15227-15232
Keywords: "Diversity-oriented synthesis"

132 Will  Farnaby, Joan  Mayol Llinas and Adam  Nelson , "Modular synthesis of thirty lead-like scaffolds suitable for CNS drug discovery", Chem. Commun. 2017, 53, 12345-12348
Keywords: "Diversity-oriented synthesis"

131 Jorg  Benningshof, Fabrizio  Giordanetto, Philip  Jones, Gerhard  Muller, Adam  Nelson , Andrew  Pannifer, Dimitrios  Tzalis and Stan   van Boeckel, "European Lead Factory", in Comprehensive Medicinal Chemistry III (eds. S. Chackalamannil, D. P. Rotella and S. E. Ward) 2017, 1, 505-519

130 George   Burslem , Thomas  Edwards , Hannah  Kyle , Adam  Nelson and Andrew  Wilson , "Hypoxia inducible factor (HIF) as a model for studying inhibition of protein-protein interactions", Chem. Sci. 2017, 8, 4188-4202
Keywords: "Chemical Genetics"

129 Katherine  Abrahams, Del  Besra, Mark  Dow , Adam  Nelson , Luis  Vaz and Stuart  Warriner , "Modular Synthesis of Diverse Natural Product-like Macrocycles: Discovery of Hits with Antimycobacterial Activity", Chem. Eur. J. 2017, 23, 7207-7211
Keywords: "Chemical Genetics" "Diversity-oriented synthesis"

128 Shiao  Chow and Adam  Nelson , "Embarking on a Chemical Space Odyssey", J. Med. Chem. 2017, 60, 3591-3593
Keywords: "Diversity-oriented synthesis"

127 James  Ault , Alan  Berry , Adam  Nelson , Arwen  Pearson , Katie  Simmons, Chi  Trinh and Claire  Windle , "Extending enzyme molecular recognition with an expanded amino acid alphabet", Proc. Natl. Acad. Sci. USA 2017, 114, 2610-1615
Keywords: "Directed evolution"

126 Andy  Ayscough, Will  Farnaby, Joan  Mayol Llinas and Adam  Nelson , "Assessing molecular scaffolds for CNS drug discovery", Drug Discov. Today 2017, 22, 965-969
Keywords: "Diversity-oriented synthesis"

125 Alan  Berry , Adam  Nelson and Claire  Windle , "Aldolase-catalysed stereoselective synthesis of fluorinated small molecules", Curr. Opin. Chem. Biol. 2017, 37, 33-38
Keywords: "Directed evolution"

124 Daniel  Foley , Steve  Marsden and Adam  Nelson , "Evaluating New Chemistry to Drive Molecular Discovery: Fit for Purpose?", Angew. Chem. Int Ed. 2016, 55, 13650-13657
Keywords: "Diversity-oriented synthesis"

123 Philip  Craven , James  Firth , Matthew  Lilburn, Steve  Marsden , Adam  Nelson and Axel  Pahl, "A Biosynthesis-Inspired Approach to over Twenty Diverse Natural Product-Like Scaffolds", Chem. Commun. 2016, 52, 9837-9840
Keywords: "Diversity-oriented synthesis"

122 Ian  Churcher, Ignacio  Colomer Utrera , Philip  Craven , Richard  Doveston , Christopher  Empson, Steve  Marsden , Adam  Nelson and Zach  Owen, "A divergent synthetic approach to diverse molecular scaffolds: assessment of lead-likeness using LLAMA, an open access computational tool", Chem. Commun. 2016, 52, 5209-5212
Keywords: "Diversity-oriented synthesis"

121 Alan  Berry , James  Howard , Marion  Muller and Adam  Nelson , "An enantio- and diastereoselective chemoenzymatic synthesis of alpha-fluoro beta-hydroxy carboxylic esters", Angew. Chem. Int. Ed. 2016, 55, 6767-6770
Keywords: "Directed evolution"

120 Alex   Breeze , George   Burslem , Thomas  Edwards , Hannah  Kyle , Adam  Nelson , P  Prabhakaran, Stuart  Warriner and Andrew  Wilson , "Synthesis of highly functionalised oligobenzamide proteomimetic foldamers by late stage introduction of sensitive groups", Org. Biomol. Chem. 2016, 14, 3782-3786
Keywords: "Chemical Genetics"

119 Alex   Breeze , George   Burslem , Thomas  Edwards , Hannah  Kyle , Adam  Nelson , Stuart  Warriner and Andrew  Wilson , "Towards ‘bionic’ proteins: replacement of continuous sequences from HIF-1alpha with proteomimetics to create functional p300 binding HIF-1alpha mimics", Chem. Commun. 2016, 52, 5421-5424
Keywords: "Chemical Genetics"

118 Jorg  Huser, Philip  Jones, Christopher  Kallus and Adam  Nelson , "The European Lead Factory", Small Molecule Medicinal Chemistry: Strategies and Technologies, eds. W. Czechtizky and P. Hamley, Wiley, 2015,

117 Alan  Berry , Adam  Daniels , Tom  Harman , Tomas  Lebl, Keith   Mullholland, Adam  Nelson , Arwen  Pearson, Jennifer  Stockwell , Chi  Trinh , Claire  Windle and Thomas  Woodhall , "Evaluation of fluoropyruvate as nucleophile in reactions catalysed by N-acetyl neuraminic acid lyase variants: scope, limitations and stereoselectivity", Org. Biomol. Chem. 2015, , in press
Keywords: "Directed evolution"

116 Anthony  Aimon , Mark  Dow , George  Karageorgis , Adam  Nelson and Stuart  Warriner , "Activity-directed Synthesis with Intermolecular Reactions: Development of a Fragment into a Range of Androgen Receptor Agonists", Angew. Chem. Int. Ed. 2015, 54, 13538-13544
Keywords: "Diversity-oriented synthesis"

115 Jorg  Benningshof, Fabrizio  Giordanetto, Daniel  Hamza, Tuomo  Kalliokoski, Anna  Karawajczyk, Remy  Morgantin , Gerhard  Muller, Adam  Nelson , Alex  Piochet, Kees  Pouwer and Dimitrios  Tzalis, "Expansion of chemical space for collaborative lead generation and drug discovery: the European Lead Factory perspective", Drug Discov. Today 2015, , in press
Keywords: "Diversity-oriented synthesis"

114 James  Firth , Richard  Foster , Rachel  Guilleux, Tuomo  Kalliokoski, Steve  Marsden , Remy  Morgantin , Adam  Nelson , Stuart  Warriner and Rong  Zhang , "Exploitation of the Ugi-Joullié reaction in the synthesis of libraries of drug-like bicyclic hydantoins", Synthesis 2015, , 2391-2406
Keywords: "Diversity-oriented synthesis"

113 Alex   Breeze , George   Burslem , Thomas  Edwards , Hannah  Kyle , Adam  Nelson , Jonathan  Stott, Darren  Tomlinson , Stuart  Warriner , Kate  Wickson and Andrew  Wilson , "Exploration of the HIF-1alpha/p300 binding interface using peptide and adhiron phage display technologies to locate binding hot-spots for inhibitor development", Mol. Biosys. 2015, 11, 2738-2749
Keywords: "Chemical Genetics"

112 Ian  Churcher, Richard  Doveston , Daniel  Foley , Steve  Marsden and Adam  Nelson , "A systematic approach to diverse, lead-like scaffolds from alpha,alpha-disubstituted amine acids", Chem. Commun. 2015, 51, 11174-11177
Keywords: "Diversity-oriented synthesis"

111 Adam  Nelson and Didier  Roche, "Innovative Approaches to the Design and Synthesis of Small Molecule Libraries", Bioorg. Med. Chem. 2015, 23, 2613
Keywords: "Diversity-oriented synthesis"

110 Ololade  Adeniji, George   Burslem , Ignacio  Colomer Utrera , Philip  Craven , Richard  Foster , Tuomo  Kalliokoski, Steve  Marsden , Adam  Nelson , Martin  Rasmussen and Anthony  Willaume, "Aminomethylhydroxylation of alkenes: Exploitation in the synthesis of scaffolds for small molecule libraries", Bioorg. Med. Chem. 2015, , in press
Keywords: "Diversity-oriented synthesis"

109 Anthony  Aimon , Philip  Craven , Mark  Dow , Nicolas  Fleury-Bregeot, Richard  Foster , Rachel  Guilleux, Tuomo  Kalliokoski, Steve  Marsden , Remy  Morgantin , Adam  Nelson and Didier  Roche , "Design, synthesis and decoration of molecular scaffolds for exploitation in the production of alkaloid-like libraries", Bioorg. Med. Chem. 2015, , doi:10.1016/j.bmc.2014.12.048
Keywords: "Diversity-oriented synthesis"

108 Amanda  Campbell , Ian  Churcher, Richard  Doveston , Mark  Dow , Daniel  Foley , David  House , Ho Yin (John)  Li , Steve  Marsden , Adam  Nelson and Paolo  Tosatti , "A unified lead-oriented synthesis of over fifty molecular scaffolds", Org. Biomol. Chem. 2015, 13, 859-865
Keywords: "Diversity-oriented synthesis"

107 George  Karageorgis , Adam  Nelson and Stuart  Warriner , "Efficient discovery of bioactive scaffolds by activity-directed synthesis", Nature Chem. 2014, 6, 872-876
This paper was featured on the front cover, and in the editorial, a News & Views article, an interview and a themed web issue.
Keywords: "Diversity-oriented synthesis"

106 Amanda  Campbell , Joachim  Horn , David  House , Ho Yin (John)  Li , Steve  Marsden and Adam  Nelson , "A convergent rhodium-catalysed asymmetric synthesis of tetrahydroquinolines", Chem. Commun. 2014, 50, 10222-10224
Keywords: "Diversity-oriented synthesis"

105 Alex   Breeze , George   Burslem , Thomas  Edwards , Hannah  Kyle , Adam  Nelson , Stuart  Warriner and Andrew  Wilson , "Small Molecule Proteomimetic Inhibitors of the HIF-1alpha/p300 Protein-Protein Interaction", ChemBioChem 2014, 14, 1083-1087
Keywords: "Chemical Genetics"

104 George   Burslem , Andrew  Grant , Tom   James , Paul  MacLellan , Adam  Nelson , Iain  Simpson , Sri  Sridharan and Stuart  Warriner , "A modular lead-oriented synthesis of diverse piperazine, 1,4-diazepane and 1,5-diazocane scaffolds", Org. Biomol. Chem. 2014, 12, 2584-2591
Keywords: "Diversity-oriented synthesis"

103 Alan  Berry , Marion  Muller , Adam  Nelson and Claire  Windle , "Engineering aldolases as biocatalysts", Curr. Opin. Chem. Biol. 2014, 19, 25-33
Keywords: "Directed evolution"

102 Sandra  Bell, Jackie  Bond, Julie  Higgins, Heather  Martin , Ewan  Morrison, Adam  Nelson , Darren  Tomlinson and Stuart  Warriner , "High-Content, High-Throughput Screening for the Identification of Cytotoxic Compounds Based on Cell Morphology and Cell Proliferation Markers", Plos ONE 2014, 9, e88338
Keywords: "Chemical Genetics"

101 Alan  Berry , Amanda  Bolt , Ivan  Campeotto , Adam  Daniels , Adrian   Mulholland , Adam  Nelson , Arwen  Pearson , Simon  Phillips and Marc  van der Kamp , "The reaction mechanism of N-acetylneuraminic acid lyase revealed by a combination of crystallography, QM/MM simulation and mutagenesis", ACS Chem. Biol. 2014, 9, 1025-1032
Keywords: "Directed evolution"

100 Andrew  Grant , Tom   James , Adam  Nelson , Iain  Simpson and Sri  Sridharan , "Modular, gold-catalysed approach to the synthesis of lead-like piperazine scaffolds", Org. Lett. 2013, 15, 6094-6097
This fact was highlighted in Synfacts.
Keywords: "Diversity-oriented synthesis"

99 Ramkrishna  Basak , Martin  Fisher , Colin  Fishwick , Arnout  Kalverda , Adam  Nelson and Bruce  Turnbull, "Discovery of novel FabF ligands inspired by platensimycin by integrating structure-based design with diversity-oriented synthetic accessibility", Org. Biomol. Chem. 2014, 12, 486-494
Keywords: "Chemical Genetics" "Diversity-oriented synthesis"

98 Richard  Doveston , Steve  Marsden and Adam  Nelson , "Towards the realisation of lead-oriented synthesis", Drug Discov. Today 2014, 7, 813-819
Keywords: "Diversity-oriented synthesis"

97 James  Ault , Alan  Berry , Adam  Nelson , Arwen  Pearson, Anna  Polyakova , Nicole  Timms , Chi  Trinh and Claire  Windle , "Structural insights into the recovery of aldolase activity in N-acetylneuraminic acid lyase by replacement of the catalytically active lysine with gamma-thialysine by using a chemical mutategenesis strategy", ChemBioChem 2013, 13, 474-481
Keywords: "Directed evolution"

96 Mark  Dow , Sushil  Maurya , Adam  Nelson and Stuart  Warriner , "Synthesis of skeletally diverse alkaloid-like molecules: exploitation of metathesis substrates assembled from triplets of building blocks", Beil. J. Org. Chem. 2013, 9, 775-785
Keywords: "Diversity-oriented synthesis"

95 Mark  Dow , Francesco  Marchetti and Adam  Nelson , "Diversity-oriented synthesis of natural product-like libraries", Diversity-oriented synthesis, ed. A. Trabocchi 2013, , chapter 9, pp 291-323
Keywords: "Diversity-oriented synthesis"

94 Paul  MacLellan and Adam  Nelson , "A conceptual framework for analysing and planning synthetic approaches to diverse lead-like scaffolds", Chem. Commun. 2013, , 2383-2393
Keywords: "Diversity-oriented synthesis"

93 Alan  Berry , Tilly  Bingham , Tom  Harman , Angela  Kinnell and Adam  Nelson , "Development of an organo- and enzyme-catalysed one-pot, sequential three-component reaction", Tetrahedron 2012, 68, 7719-7722
Keywords: "Directed evolution"

92 Alan  Berry , Adam  Daniels , Adam  Nelson and Nicole  Timms , "Directed Evolution and (Semi-) Rational Design Strategies for the Creation of Synthetically Useful, Stereoselective Biocatalysts", Comprehensive Chirality 2012, , in press
Keywords: "Directed evolution"

91 Steve  Marsden , Adam  Nelson and Paolo  Tosatti , "Recent advances and applications of iridium-catalysed asymmetric allylic substitution", Org. Biomol. Chem 2012, 10, 3157-3163
Keywords: "Stereochemically diverse libraries"

90 Catherine  Joce , Adam  Nelson , Peter  Stockley, Stuart  Warriner and Rebecca  White, "Design, Synthesis and In Vitro Evaluation of Novel Bivalent S-Adenosylmethionine Analogues", Bioorg. Med. Chem. Lett. 2012, 22, 278-284
Keywords: "Chemical Genetics"

89 Mark  Dow , Martin  Fisher , Tom   James , Francesco  Marchetti and Adam  Nelson , "Towards the systematic exploration of chemical space", Org. Biol. Chem. 2012, , in press
This article has been highlighted as a "hot" article
Keywords: "Chemical Genetics" "Diversity-oriented synthesis"

88 Amanda  Campbell , David  House , Steve  Marsden , Adam  Nelson and Paolo  Tosatti , "Control in Sequential Asymmetric Allylic Substitution: Stereodivergent Access to N,N-Diprotected Unnatural Amino Acids", J. Org. Chem. 2011, 76, 5495-5501
Keywords: "Diversity-oriented synthesis"

87 Heather  Bone , Adam  Nelson and Melanie  Welham, "A novel chemically directed route for the generation of definitive endoderm from human embryonic stems cells based on inhibition of GSK-3", J. Cell Sci. 2011, 124, 1992-2000
Keywords: "Chemical Genetics"

86 Christian  Einzinger , Sushil  Maurya , Ben  McKeever-Abbas , Sarah  Murrison and Adam  Nelson , "Synthesis of Skeletally-Diverse Alkloid-like Small Molecules", Eur. J. Org. Chem. 2011, , 2354-2359
Keywords: "Diversity-oriented synthesis"

85 Martin  Fisher and Adam  Nelson , "The Chemical Genetic Approach: The Interrogation of Biological Mechanisms with Small Molecule Probes", New Frontiers in Chemical Biology: Enabling Drug Discovery, ed. M. E. Bunnage 2011,
Keywords: "Chemical Genetics" "Diversity-oriented synthesis"

84 Amanda  Campbell , Joachim  Horn , David  House , Adam  Nelson and Paolo  Tosatti , "Iridium-Catalyzed Asymmetric Allylic Amination with Polar Amines: Access to Building Blocks with Lead-Like Molecular Properties", Adv. Synth. Cat. 2010, 352, 3153-3157
Keywords: "Diversity-oriented synthesis"

83 Alan  Berry , Amanda  Bolt , Ivan  Campeotto , Catriona  Dennis, Tom  Harman , Adam  Nelson , Arwen  Pearson and Simon  Phillips, "Structural Insights into Substrate Specificity in Variants of N-Acetylneuraminic Acid Lyase Produced by Directed Evolution", J. Mol. Biol. 2010, 404, 56-69
Keywords: "Directed evolution"

82 Christopher  Brain, Anqi  Chen, Adam  Nelson , N.  Tanikkul and E. J.  Thomas , "Synthesis of macrocyclic precursors of lankacidins using Stille reactions of 4-(2-iodo-alkenyl)azetidinones and related compounds for ring closure", Tetrahedron 2010, 66, 6613-6625

81 Jerome  Hayes, Tom   James , Tom  Lanyon-Hogg , Stuart  Leach , Adam  Nelson , Catherine  O'Leary-Steele and Palle  Pedersen , "Synthesis of Small Molecules with High Scaffold Diversity: Exploitation of Metathesis Cascades in Combination with Inter- and Intramolecular Diels-Alder Reactions", Chem. Eur. J. 2010, , 9563-9671
Keywords: "Diversity-oriented synthesis"

80 Alan  Berry , Louise  Horsfall and Adam  Nelson , "Identification and characterization of important residues in the catalytic mechanism of CMP-Neu5Ac synthetase from Neisseria meningitides", FEBS J. 2010, 277, 2779-2790
Keywords: "Directed evolution"

79 Amanda  Campbell , Joachim  Horn , David  House , Ho Yin (John)  Li , Steve  Marsden , Adam  Nelson , Rachel  Shearer and Gordon  Weingarten , "Convergent synthesis of dihydroquinolones from o-aminoarylboronates", Tetrahedron 2009, 65, 9002-9007
Keywords: "Diversity-oriented synthesis"

78 Alan  Berry , Ivan  Campeotto , Stephen  Carr , Adam  Nelson , Arwen  Pearson , Simon  Phillips and Chi  Trinh , "Structure of an Escherichia coli N-acetyl-D-neuraminic acid lyase mutant, E192N, in complex with pyruvate at 1.45 A resolution", Acta Cryst. F 2009, F65, 1088-1090
Keywords: "Directed evolution"

77 Chris  Cordier , Jerome  Hayes, Adam  Nelson , Catherine  O'Leary-Steele and Stuart  Warriner , "A fluorous-tagged Safety Catch Linker for Preparing Heterocycles by Ring-Closing Metathesis", Org. Lett. 2009, 11, 915-918
Keywords: "Diversity-oriented synthesis"

76 Steve  Bartlett , Christian  Einzinger , David  Glowacki , Ben  McKeever-Abbas , Sarah  Murrison , Adam  Nelson , James  Titchmarsh and Stuart  Warriner , "Remarkably slow rotation about a single bond between an sp3-hybridised carbon and an aromatic ring without ortho substituents", Chem. Eur. J. 2009, 15, 2185-2189
Keywords: "Diversity-oriented synthesis"

75 Jamie  Caryl , Catherine  Joce , Adam  Nelson , Peter  Stockley and Stuart  Warriner , "Identification of stable S-adenosylmethionine (SAM) analogues derivatised with bioorthogonal tags: Effect of ligands on the affinity of the E. coli methionine repressor, MetJ, for its operator DNA", Org. Biomol. Chem. 2009, 7, 635-638
Keywords: "Chemical Genetics"

74 Chris  Cordier , Stuart  Leach , Daniel  Morton , Adam  Nelson and Stuart  Warriner , "Synthesis of natural product-like molecules with over eighty distinct skeletons", Angew. Chemie. Int. Ed. 2009, 48, 104-109
This VIP paper was featured in News and Views articles in Nature (Schreiber) and Nature Chem Biol (Waldmann); highlights in Angew Chem (Spring) and Nature Chem; articles in Science and C&E News; and noted as "Exceptional" by the Biology faculty of 1000
Keywords: "Chemical Genetics" "Diversity-oriented synthesis"

73 Steve  Bartlett , Heather  Bone , Teresa  Damiano , Julie  Letchford , Adam  Nelson , Alexis  Perry and Melanie  Welham, "Involvement of glycogen synthase kinase-3 in regulation of murine embryonic stem cell self-renewal revealed by a series of bisindolylmaleimides", Chem. Biol. 2008, 16, 15-27
This paper has been identified as a feature article by the journal. The research was reported by the Daily Telegraph and the London Evening Standard. The research was highlighted in Cell Stem Cell and Chemical and Engineering News.
Keywords: "Chemical Genetics"

72 Joachim  Horn , David  House , Steve  Marsden , Adam  Nelson and Gordon  Weingarten , "Convergent, Regiospecific Synthesis of Quinolines from o-Aminophenylboronates ", Org. Lett. 2008, 10, 4117-4120
This paper was featured on Synfacts.
Keywords: "Diversity-oriented synthesis"

71 Chris  Cordier , Stuart  Leach , Daniel  Morton , Adam  Nelson , Catherine  O'Leary-Steele , Stuart  Warriner and Thomas  Woodhall , "An efficient method for synthesising unsymmetrical silaketals: substrates for ring-closing, including macrocycle-closing, metathesis", Org. Biomol. Chem. 2008, 6, 1734-1737
Click above for open access to the manuscript
Keywords: "Diversity-oriented synthesis"

70 Chris  Cordier , Daniel  Morton , Sarah  Murrison , Adam  Nelson and Catherine  O'Leary-Steele , "Natural products as an inspiration in the diversity-oriented synthesis of bioactive compound libraries", Nat. Prod. Rep. 2008, , 719-737
Click above for open access to the manuscript
Keywords: "Chemical Genetics" "Diversity-oriented synthesis"

69 Chris  Cordier , Stuart  Leach , Gordon  McKiernan , Daniel  Morton , Adam  Nelson and Stuart  Warriner , "A fluorous-tagged linker from which small molecules are released by ring-closing metathesis", J. Org. Chem. 2008, 73, 2752-2759
Available in open access format through ACS AuthorChoice: click on the title above
Keywords: "Diversity-oriented synthesis"

68 Alan  Berry , Amanda  Bolt and Adam  Nelson , "Directed evolution of aldolases for exploitation in synthetic organic chemistry", Arch. Biochem. Biophys. 2008, 474, 318-330
Keywords: "Directed evolution"

67 Teresa  Damiano , Daniel  Morton and Adam  Nelson , "Photochemical transformations of pyridinium salts: mechanistic studies and applications in synthesis", Org. Biomol. Chem. 2007, 5, 2735-2752
Open Access Version - provided courtesy of the RSC

66 Chris  Cordier , Stuart  Leach and Adam  Nelson , "1,3-Dioxetanes and 1,3-Dioxolanes", Science of Synthesis ed. S. Warriner, 2007, 29, 407-486

65 Karen  Dodd , Daniel  Morton , Robert  Narquizian, Adam  Nelson and Stephen  Worden , "Desymmetrisation of a Centrosymmetric Molecule by Carbon-Carbon Bond Formation: Asymmetric Aldol Reactions of a Centrosymmetric Dialdehyde", Chem. Eur. J. 2007, 13, 5857-5861
Open Access Version
Keywords: "New strategies for asymmetric synthesis"

64 Robert  Hodgson , Andrew  Kennedy , Adam  Nelson and Alexis  Perry , "Synthesis of 3-sulfonyloxypyridines: Oxidative ring expansion of α-furylsulfonamides and N→O sulfonyl transfer", Synlett 2007, , 1043-1046
Open Access Version - provide courtesy of Georg Springer Verlag

63 Chris  Adams, Alison  Ashcroft, Andy  Baron, Blandine  Clique , Alan  Ironmonger , Adam  Nelson , Peter  Stockley and Ben  Whittaker , "Scanning conformational space with a library of stereo- and regiochemically diverse aminoglycoside derivatives: The discovery of new ligands for RNA hairpin sequences", Org. Biomol. Chem. 2007, 5, 1081-1086
Open Access Version
Keywords: "Stereochemically diverse libraries" "Chemical Genetics"

62 Craig  Beck, Heather  Bone , Pierre-Yves   Bourillot, Teresa  Damiano , Adam  Nelson , Pierre  Savatier, Valerie  Schreiber, Mike   Storm and Melanie  Welham, "Regulation of Nanog expression by phosphoinositide 3-kinase-dependent signalling in murine embryonic stem cells ", J. Biol. Chem. 2007, 282, 6265-6273
Open Access Version - provided courtesy of, and copyright held by, the American Society of Biochemistry and Molecular Biology
Keywords: "Chemical Genetics"

61 Alan  Berry , Lorna  Farnsworth , Adam  Nelson , Gavin  Williams and Thomas  Woodhall , "Creation of a Pair of Stereochemically Complementary Biocatalysts", J. Am. Chem. Soc. 2006, 128, 16238-16247
This paper describes the first example of the directed evolution of a pair of enzymes catalysing C-C bond formations with complementary stereochemical courses
Keywords: "Stereochemically diverse libraries" "Directed evolution"

60 Mark  Anstiss and Adam  Nelson , "Catalytic and stoichiometric approaches to the desymmetrisation of centrosymmetric piperazines by enantioselective acylation: A total synthesis of Dragmacidin A", Org. Biomol. Chem. 2006, 4, 4135-4143
Open Access Version - provided courtesy of the RSC
Keywords: "New strategies for asymmetric synthesis" "Natural product synthesis"

59 Claire  Crawford , Adam  Nelson and Ian  Patel , "Development of an Approach to the Synthesis of the ABC Ring System of Hemibrevetoxin B", Org. Lett. 2006, 8, 4231-4234
Keywords: "Natural product synthesis"

58 Adam  Nelson , "Building bridges between Chemistry and Biology", RSC Chemical Biology Forum Newsletter Autumn 2005, , 3-4
Keywords: "Chemical Genetics"

57 Adam  Nelson and Peter  Stockley, "Novel Antibacterial and Antiviral Agents", PCT Application , , WO 2005/116041

56 Chris  Cordier and Adam  Nelson , "Reaching the target: small molecules aim to probe barrier quality", ChemBioChem , 6, 1953-1955
Open Access Version - provided courtesy of John Wiley and Sons
Keywords: "Chemical Genetics"

55 Alex  Bullock, J. E.  Debreczeni, O. Y.  Fedorov, Stefan  Knapp, Brian  Marsden and Adam  Nelson , "Structural Basis of Inhibitor Specificity of the Human Protooncogene Proviral Insertion Site in Moloney Murine Leukemia Virus (PIM-1) Kinase", J. Med. Chem. 2005, 48, 7604-7614
Keywords: "Stereochemically diverse libraries" "Chemical Genetics"

54 Simon  Barrett , Steve  Bartlett , Amanda  Bolt , Alan  Ironmonger , Catherine  Joce , Adam  Nelson and Thomas  Woodhall , "Configurational stability of bisindolylmaleimide cyclophanes: From conformers to the first configurationally stable, atropisomeric bisindolylmaleimides", Chem. Eur. J. 2005, 11, 6277-6285
Open Access Version
Keywords: "Stereochemically diverse libraries"

53 Andrew  Kennedy , Adam  Nelson and Alexis  Perry , "Methods for the synthesis of polyhydroxylated piperidines by diastereoselective dihydroxylation: Exploitation in the two-directional synthesis of aza-C-linked disaccharide derivatives", Beilstein J. Org. Chem. 2005, 1, 2
This is the inaugural paper in Beilstein Journal of Organic Chemistry.
Keywords: "Stereochemically diverse libraries" "New strategies for asymmetric synthesis"

52 Steve  Bartlett , Godfrey  Beddard, Richard  Jackson, Veysel  Kayser, Colin  Kilner , Andrew  Leach, Adam  Nelson , Peter  Oledzki, Peter  Parker, Gavin  Reid and Stuart  Warriner , "Comparison of the ATP binding sites of Protein Kinases using conformationally diverse bisindolylmaleimides", J. Am. Chem. Soc. 2005, 127, 11699-11708
This work was featured in an article in Chemical and Engineering News which focused on macrocyclisation as a tool in drug discovery.
Keywords: "Stereochemically diverse libraries" "Chemical Genetics"

51 Alan  Berry , Adam  Nelson , Gavin  Williams and Thomas  Woodhall , "Structure-guided saturation mutagenesis of N-acetylneuraminic acid lyase for the synthesis sialic acid mimetics", Prot. Eng. Des. Sel. 2005, 18, 239-246
Keywords: "Stereochemically diverse libraries" "Directed evolution"

50 Blandine  Clique , Jackie  Colley , Alan  Ironmonger , Adam  Nelson , Peter  Stockley, James  Titchmarsh and Ben  Whittaker , "Synthesis of a library of stereo- and regiochemically diverse aminoglycoside derivatives", Org. Biomol. Chem. 2005, 3, 2776-2785
Open Access Version - provided courtesy of the RSC
Keywords: "Stereochemically diverse libraries" "Chemical Genetics"

49 Alan  Berry , Adam  Nelson , Gavin  Williams and Thomas  Woodhall , "Creation of an aldolase for the parallel synthesis of sialic acid mimetics", Angew. Chem., Int. Ed. 2005, 44, 2109-2112
Open Access Version
Keywords: "Stereochemically diverse libraries" "Directed evolution"

48 Alan  Ironmonger , Adam  Nelson and Peter  Stockley, "Asymmetric double ring-opening of a C2h-symmetric bisepoxide: Improved enantiomeric excess of the product through enantioselective desymmetrisation and ‘proof-reading’ steps", Org. Biomol. Chem. 2005, 3, 2350-2353
Open Access Version - provided courtesy of the RSC
Keywords: "New strategies for asymmetric synthesis"

47 Andrew  Kennedy , Adam  Nelson and Alexis  Perry , "A general, two-directional synthesis of aza-(1 to 1’)-C-disaccharide mimetics", Chem. Commun. 2005, , 1646-1648
Open Access Version - provided courtesy of the RSC
Keywords: "Stereochemically diverse libraries"

46 Alan  Berry , Adam  Nelson , Gavin  Williams and Thomas  Woodhall , "Synthesis of screening substrates for the directed evolution of sialic acid aldolase: Towards tailored enzymes for the preparation of influenza A sialidase inhibitor analogues", Org. Biomol. Chem. 2005, 3, 1795-1800
Open Access Version - provided courtesy of the RSC
Keywords: "Stereochemically diverse libraries" "Directed evolution"

45 Adam  Nelson , "3-Oxidopyrylium salts and their thio and benzo-fused analogues", Science of Synthesis 2003, 14, 639-647, ed. E. J. Thomas

44 Adam  Nelson , "Ynones", Science of Synthesis 2004, 26, eds. J. Cossy and E. J. Thomas

43 Alan  Berry , Adam  Nelson and Gavin  Williams , "Directed Evolution of Enzymes for Biocatalysis and the Life Sciences", Cell. Mol. Life Sci. 2004, 61, 3034-3046
Keywords: "Directed evolution"

42 Adam  Nelson , "The development of strategies and methods for the synthesis of biologically active compounds", New J. Chem. 2004, 28, 771-776
Open Access Version - provided courtesy of the RSC
Keywords: "Stereochemically diverse libraries" "New strategies for asymmetric synthesis" "Natural product synthesis"

41 Andrew  Kennedy , Adam  Nelson and Alexis  Perry , "Highly diastereoselective addition of ketone enolates to N-sulfinyl imines: Asymmetric synthesis of syn- and anti-1,3-amino alcohol derivatives", Synlett 2004, , 967-970
Keywords: "Stereochemically diverse libraries"

40 Steve  Bartlett and Adam  Nelson , "Evaluation of alternative approaches for the synthesis of macrocyclic bisindolylmaleimides", Org. Biomol. Chem. 2004, 2, 2874-2883
Open Access Version - provided courtesy of the RSC
Keywords: "Stereochemically diverse libraries"

39 Steve  Bartlett and Adam  Nelson , "Towards configurationally stable bisindolylmaleimide cyclophanes: Potential tools for investigating protein kinase function", Chem. Commun. 2004, , 1112-1113
Open Access Version - provided courtesy of the RSC
Keywords: "Stereochemically diverse libraries" "Chemical Genetics"

38 Robert  Hodgson and Adam  Nelson , "A two-directional synthesis of the C58-C71 fragment of palytoxin", Org. Biomol. Chem. 2004, 2, 373-386
Open Access Version - provided courtesy of the RSC
Keywords: "Natural product synthesis"

37 Adam  Nelson , "Benzothiopyranones", Science of Synthesis 2003, 14, 787-816, ed. E. J. Thomas

36 Adam  Nelson , "Asymmetric phase transfer catalysis", Organic Synthesis Highlights V 2003, , 125-133, eds. H.-G. Schmaltz and T. Wirth

35 Mark  Anstiss , Joanne  Holland , Adam  Nelson and James  Titchmarsh , "Beyond breaking the mirror plane: The desymmetrisation of centrosymmetric molecules as an efficient strategy for asymmetric synthesis", Synlett 2003, , 1213-1220
Keywords: "New strategies for asymmetric synthesis" "Natural product synthesis"

34 Chrissie  Carter , Sarah  Fletcher and Adam  Nelson , "Towards phase-transfer catalysts with a chiral anion: Inducing asymmetry in the reactions of cations", Tetrahedron: Asymmetry 2003, 14, 1995-2004

33 Alan  Berry , Silvie  Domann , Adam  Nelson and Gavin  Williams , "Modifying the stereochemistry of an enzyme-catalysed reaction by directed evolution", Proc. Natl. Acad. Sci. USA 2003, 100, 3143-3148
The use of directed evolution to modify the stereochemical course of enzyme-catalysed C-C bond formation is described for the first time.
Keywords: "Directed evolution"

32 Joanne  Holland , Mark  Lewis and Adam  Nelson , "Desymmetrisation of a Centrosymmetric Diepoxide: Efficient Synthesis of a Key Intermediate in a Total Synthesis of Hemibrevetoxin B", J. Org. Chem. 2003, 68, 747-753
The desymmetrisation of centrosymmetric molecules as a tactic in natural product synthesis is described for the first time. The research is featured in the textbook "Fundamentals of Asymmetric Catalysis" and Hoffmann's meso compound review (Angew. Chem)
Keywords: "New strategies for asymmetric synthesis" "Natural product synthesis"

31 Steve  Bartlett , Robert  Hodgson , Joanne  Holland , Matthew  Jones , Colin  Kilner , Adam  Nelson and Stuart  Warriner , "Exploiting predisposition in the stereoselective synthesis of mono-, bi- and tetracyclic oxygen heterocycles: Equilibration between, and trapping of, alternative di- and tetraacetals", Org. Biomol. Chem. 2003, 1, 2393-2402
Open Access Version - provided courtesy of the RSC
Keywords: "Stereochemically diverse libraries" "New strategies for asymmetric synthesis"

30 Alan  Berry , Adam  Nelson and Venti  Suryanti, "Cloning, over-expression, purification and chacterisation of N-acetylneuraminate synthase from Streptococcus agalactiae", Prot. Express. Purif. 2003, 27, 346-356
Keywords: "Directed evolution"

29 Michael  Harding , Robert  Hodgson , Tahir  Majid , Kenny  McDowall and Adam  Nelson , "A stereodivergent, two-directional synthesis of stereoisomeric C-linked disaccharide mimetics", Org. Biomol. Chem. 2003, 1, 338-349
Open Access Version - provided courtesy of the RSC
Keywords: "Stereochemically diverse libraries" "New strategies for asymmetric synthesis"

28 Michael  Harding , Robert  Hodgson and Adam  Nelson , "Sequential kinetic resolution of C2-symmetric compounds as a key step in two-directional synthesis: Structural requirements for efficient resolution of difuryl diols", J. Chem. Soc., Perkin Trans. 1 2002, , 2403-2413
Open Access Version - provided courtesy of the RSC
Keywords: "New strategies for asymmetric synthesis"

27 Robert  Hodgson , Tahir  Majid and Adam  Nelson , "Desymmetrisation of meso difuryl alcohols, diols and their derivatives: complementary directed and undirected asymmetric dihydroxylation reactions", J. Chem. Soc., Perkin Trans. 1 2002, , 1631-1643
Open Access Version - provided courtesy of the RSC
Keywords: "Stereochemically diverse libraries" "New strategies for asymmetric synthesis"

26 Robert  Hodgson , Tahir  Majid and Adam  Nelson , "Towards complete stereochemical control: complementary methods for the synthesis of six diastereoisomeric monosaccharide mimetics", J. Chem. Soc., Perkin Trans. 1 2002, , 1444-1454
Open Access Version - provided courtesy of the RSC
Keywords: "Stereochemically diverse libraries"

25 Joanne  Holland , Mark  Lewis and Adam  Nelson , "First desymmetrisation of a centrosymmetric molecule in natural product synthesis: Preparation of a key fragment in the synthesis of Hemibrevetoxin B", Angew. Chem., Int. Ed. 2001, 40, 4082-4084
The desymmetrisation of centrosymmetric molecules as a tactic in natural product synthesis is described for the first time. The research is featured in the textbook "Fundamentals of Asymmetric Catalysis" and Hoffmann's meso compound review (Angew. Chem)
Keywords: "New strategies for asymmetric synthesis" "Natural product synthesis"

24 Adam  Nelson , "Looking in the mirror", Chemistry Review 2001, 10, issue 3, 6-9
Keywords: "New strategies for asymmetric synthesis"

23 Robert  Hodgson , Tahir  Majid and Adam  Nelson , "Directed and undirected asymmetric dihydroxylation reactions: application in the synthesis of a C-linked analogue of allolactose", Chem. Commun. 2001, , 2076-2077
Open Access Version - provided courtesy of the RSC
Keywords: "Stereochemically diverse libraries"

22 Anqi  Chen, Adam  Nelson , N.  Tanikkul and E. J.  Thomas , "An approach to the total synthesis of the lankacidins: synthesis of advanced macrocyclic precursors", Tetrahedron Lett. 2001, 42, 1251-1254

21 Christopher  Brain, Anqi  Chen, Adam  Nelson , N.  Tanikkul and E. J.  Thomas , "An approach to the total synthesis of the lankacidins: synthesis of the requisite building blocks", Tetrahedron Lett. 2001, 42, 1247-1250

20 Michael  Harding and Adam  Nelson , "A general, two-directional synthesis of C-(1 to 6)-linked carbohydrate mimetics: synthesis from non-carbohydrate-based starting materials", Chem. Commun. 2001, , 695-696
Open Access Version - provided courtesy of the RSC
Keywords: "Stereochemically diverse libraries"

19 Stuart  Green , Adam  Nelson , Stuart  Warriner and Ben  Whittaker , "Synthesis and investigation of the configurational stability of some dimethylammonium borate salts", J. Chem. Soc., Perkin Trans. 1 2000, , 4403-4408
Open Access Version - provided courtesy of the RSC

18 Tajassas  Aftab , Chrissie  Carter , Martin  Christlieb, Jenny  Hart and Adam  Nelson , "Stereospecific conversion of (1R*,3S*)- and (1R*,3R*)-3-cyclohexyl-1-phenyl-1,3-propanediol into the corresponding 2,4-disubstituted oxetanes", J. Chem. Soc., Perkin Trans. 1 2000, , 711-722

17 Tajassas  Aftab , Chrissie  Carter , Jenny  Hart and Adam  Nelson , "A method for the stereospecific conversion of 1,3-diols into oxetanes", Tetrahedron Lett. 1999, 40, 8679-8683

16 Adam  Nelson , "Asymmetric Phase-Transfer Catalysis", Angew. Chem., Int. Ed. 1999, 38, 1583-1585

15 Adam  Nelson and Stuart  Warren , "Stereocontrol with phosphine oxides: synthesis of optically active cyclopropyl ketones", J. Chem. Soc., Perkin Trans. 1 1999, , 3425-3434

14 Neil  Feeder , Gordon  Hutton, Adam  Nelson and Stuart  Warren , "Stereoselective intramolecular acylation of gamma’-benzoyloxy phosphine oxides with an internal chlorotrimethylsilane trap: isolation of silylated tetrahedral intermediates", J. Chem. Soc., Perkin Trans. 1 1999, , 3413-3424

13 Adam  Nelson and Stuart  Warren , "Control of remote stereochemistry using phosphine oxides: Formal synthesis of any stereoisomer (RR, RS, SR or SS) of a diol bearing 1,5-related stereogenic centres across an E double bond", J. Chem. Soc., Perkin Trans. 1 1999, , 1983-1998

12 Adam  Nelson and Stuart  Warren , "1,3-Stereocontrol with phosphine oxides: Asymmetric synthesis of all four diastereoisomers of a gamma’-benzyloxy beta-hydroxy phosphine oxide", J. Chem. Soc., Perkin Trans. 1 1999, , 1963-1982

11 Bjorn  Bartels, Jonathan  Clayden, C.  Gonzalez-Martin, Adam  Nelson , Matthew  Russell and Stuart  Warren , "Diastereoselective nucleophilic additions to vinyl phosphine oxides", J. Chem. Soc., Perkin Trans. 1 1999, , 1807-1822

10 Helen  Mitchell, Adam  Nelson and Stuart  Warren , "Strategies for the stereoselective synthesis of molecules with remote stereogenic centres across a double bond of fixed configuration", J. Chem. Soc., Perkin Trans. 1 1999, , 1899-1914

9 Jason  Eames, Helen  Mitchell, Adam  Nelson , Peter  O'Brien, Stuart  Warren and Paul  Wyatt, "An efficient protocol for a Sharpless-style racemic dihydroxylation", J. Chem. Soc., Perkin Trans. 1 1999, , 1095-1103

8 Bjorn  Bartels, C.  Gonzalez-Martin, Adam  Nelson , Matthew  Russell and Stuart  Warren , "Asymmetric Addition of a Chiral Lithium Amide to Prochiral Vinyl Phosphine Oxides", Tetrahedron Lett. 1998, 39, 1637-1640

7 Adam  Nelson and Stuart  Warren , "Alkenyl Diols by E-Selective Horner-Wittig Elimination: Formal Synthesis of Any Isomer (RR, RS, SR or SS) Bearing 1,5-Related Stereogenic Centres Across an E Double Bond", Tetrahedron Lett. 1998, 39, 1633-1636

6 Jonathan  Clayden, Adam  Nelson and Stuart  Warren , "Diastereoselective Reactions of Optically Active gamma-Substituted Vinyl Phosphine Oxides", Tetrahedron Lett. 1997, 38, 3471-3474

5 David  Cavalla, Catherine  Gueguen, Adam  Nelson , Peter  O'Brien, Matthew  Russell and Stuart  Warren , "Chiral Phosphine Oxides and Chiral Esters in Stereoselective Intermolecular Acylation Reactions of Phosphine Oxides", Tetrahedron Lett. 1997, 37, 7465-7468

4 Adam  Nelson and Stuart  Warren , "Asymmetric Dihydroxylation of Allylic Phosphine Oxides", J. Chem. Soc., Perkin Trans. 1 1997, , 2645-2657

3 Adam  Nelson and Stuart  Warren , "Intramolecular Acylations of gamma-Benzoyloxy Phosphine Oxides: Synthesis of Optically Active Cyclopropyl Ketones", Tetrahedron Lett. 1996, 37, 1501-1504

2 Adam  Nelson , Peter  O'Brien and Stuart  Warren , "Asymmetric Dihydroxylations of Allylic Phosphine Oxides", Tetrahedron Lett. 1995, 36, 2685-2688

1 Jason  Eames, Helen  Mitchell, Adam  Nelson , Peter  O'Brien, Stuart  Warren and Paul  Wyatt, "An Efficient Protocol for a Sharpless Style Racemic Dihydroxylation", Tetrahedron Lett. 1995, 36, 1719-1722